| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Wofford (271) | 82-75 | Won | -1.0656 | -0.0000 |
| 22-Nov-05 | vs South Alabama (65) | 85-67 | Won | 0.3853 | 1.0000 |
| 26-Nov-05 | vs Xavier OH (71) | 55-74 | Lost | 0.6744 | -0.4474 |
| 29-Nov-05 | at Florida St (47) | 57-97 | Lost | 1.2864 | 0.0000 |
| 03-Dec-05 | at Evansville (168) | 69-75 | Lost | 0.3242 | -0.7977 |
| 06-Dec-05 | vs Chicago St (228) | 69-56 | Won | -0.7664 | 0.1118 |
| 11-Dec-05 | at Loyola-Chicago (114) | 65-80 | Lost | 0.7110 | -0.4108 |
| 17-Dec-05 | vs New Orleans (221) | 68-56 | Won | -0.7084 | 0.1697 |
| 20-Dec-05 | vs IPFW (275) | 79-69 | Won | -1.0772 | -0.0000 |
| 28-Dec-05 | vs Tennessee-Martin (207) | 62-54 | Won | -0.6543 | 0.2238 |
| 30-Dec-05 | at Memphis (5) | 70-90 | Lost | 2.0794 | 0.0000 |
| 04-Jan-06 | at Northwestern (86) | 53-66 | Lost | 0.9155 | -0.2063 |
| 07-Jan-06 | at Michigan (33) | 65-68 | Lost | 1.4079 | 0.0000 |
| 11-Jan-06 | vs Ohio State (11) | 64-80 | Lost | 1.1562 | 0.0000 |
| 14-Jan-06 | vs Minnesota (70) | 72-55 | Won | 0.3297 | 1.0000 |
| 18-Jan-06 | at Penn St (94) | 54-74 | Lost | 0.8648 | -0.2571 |
| 21-Jan-06 | at Indiana (29) | 49-62 | Lost | 1.4808 | 0.0000 |
| 25-Jan-06 | vs Northwestern (86) | 76-78 | Lost | 0.2218 | -0.9001 |
| 28-Jan-06 | at Illinois (9) | 58-76 | Lost | 1.8854 | 0.0000 |
| 01-Feb-06 | vs Iowa (17) | 68-77 | Lost | 1.0314 | -0.0905 |
| 04-Feb-06 | vs Wisconsin (37) | 70-62 | Won | 0.6846 | 1.0000 |
| 08-Feb-06 | at Michigan St (30) | 52-77 | Lost | 1.4595 | 0.0000 |
| 11-Feb-06 | vs Michigan (33) | 84-70 | Won | 0.7141 | 1.0000 |
| 18-Feb-06 | vs Penn St (94) | 61-69 | Lost | 0.1710 | -0.9508 |
| 22-Feb-06 | at Minnesota (70) | 50-62 | Lost | 1.0235 | -0.0984 |
| 01-Mar-06 | vs Indiana (29) | 59-70 | Lost | 0.7870 | -0.3348 |
| 05-Mar-06 | at Ohio State (11) | 57-76 | Lost | 1.8499 | 0.0000 |
| 09-Mar-06 | at Michigan St (30) | 58-70 | Lost | 1.1126 | -0.0093 |
A red opponent rating indicates modification according to home court advantage (0.3469).