| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Marshall (231) | 91-81 | Won | -0.7787 | 0.2440 |
| 21-Nov-05 | at Loyola-Chicago (114) | 86-99 | Lost | 0.7110 | -0.2663 |
| 26-Nov-05 | at Marshall (231) | 67-70 | Lost | -0.0849 | -1.0000 |
| 03-Dec-05 | vs Purdue (148) | 75-69 | Won | -0.2250 | 0.7977 |
| 06-Dec-05 | at Western Kentucky (82) | 77-84 | Lost | 0.9672 | -0.0101 |
| 10-Dec-05 | vs Western Illinois (310) | 70-63 | Won | -1.5804 | -0.0000 |
| 17-Dec-05 | vs Campbell (311) | 83-71 | Won | -1.5865 | -0.0000 |
| 21-Dec-05 | at Austin Peay (175) | 71-74 | Lost | 0.2574 | -0.7199 |
| 28-Dec-05 | vs Drake (162) | 68-79 | Lost | -0.3417 | -1.0000 |
| 31-Dec-05 | at Northern Iowa (41) | 60-71 | Lost | 1.3470 | 0.0000 |
| 05-Jan-06 | vs Missouri St (44) | 65-80 | Lost | 0.6324 | -0.3449 |
| 07-Jan-06 | vs Indiana St (136) | 63-58 | Won | -0.1373 | 0.8854 |
| 11-Jan-06 | at Southern Illinois (35) | 38-66 | Lost | 1.3936 | 0.0000 |
| 14-Jan-06 | at Bradley (38) | 62-90 | Lost | 1.3743 | 0.0000 |
| 16-Jan-06 | at Illinois St (185) | 57-65 | Lost | 0.2183 | -0.7590 |
| 19-Jan-06 | vs Wichita St (31) | 62-69 | Lost | 0.7531 | -0.2242 |
| 22-Jan-06 | at Creighton (49) | 58-77 | Lost | 1.2472 | 0.0000 |
| 25-Jan-06 | vs Northern Iowa (41) | 61-74 | Lost | 0.6532 | -0.3241 |
| 28-Jan-06 | vs Bradley (38) | 76-79 | Lost | 0.6806 | -0.2967 |
| 01-Feb-06 | at Wichita St (31) | 66-74 | Lost | 1.4469 | 0.0000 |
| 04-Feb-06 | vs Illinois St (185) | 54-47 | Won | -0.4754 | 0.5473 |
| 07-Feb-06 | vs Creighton (49) | 56-60 | Lost | 0.5534 | -0.4239 |
| 11-Feb-06 | at Drake (162) | 69-68 | Won | 0.3520 | 1.0000 |
| 14-Feb-06 | at Missouri St (44) | 50-71 | Lost | 1.3262 | 0.0000 |
| 18-Feb-06 | vs Tennessee-Martin (207) | 62-69 | Lost | -0.6543 | -1.0000 |
| 21-Feb-06 | vs Southern Illinois (35) | 64-59 | Won | 0.6998 | 1.0000 |
| 25-Feb-06 | at Indiana St (136) | 77-75 | Won | 0.5565 | 1.0000 |
| 02-Mar-06 | vs Illinois St (185) | 52-45 | Won | -0.1286 | 0.8942 |
| 03-Mar-06 | at Southern Illinois (35) | 55-71 | Lost | 1.0467 | 0.0000 |
A red opponent rating indicates modification according to home court advantage (0.3469).