| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Central Michigan (306) | 87-60 | Won | -1.4854 | -0.0000 |
| 22-Nov-05 | at Boston U. (243) | 51-46 | Won | -0.1497 | -0.0000 |
| 26-Nov-05 | vs Butler (88) | 78-74 | Won | 0.2144 | 0.1534 |
| 29-Nov-05 | vs Miami FL (67) | 74-53 | Won | 0.3683 | 0.3073 |
| 03-Dec-05 | at Notre Dame (64) | 71-67 | Won | 1.0983 | 1.0000 |
| 07-Dec-05 | vs Delaware St (151) | 69-49 | Won | -0.2342 | -0.0000 |
| 10-Dec-05 | at South Florida (230) | 68-47 | Won | -0.0819 | -0.0000 |
| 17-Dec-05 | vs UCLA (7) | 61-68 | Lost | 1.2634 | -0.7976 |
| 22-Dec-05 | vs Miami OH (90) | 87-80 | Won | 0.1949 | 0.1339 |
| 28-Dec-05 | vs Coppin St (279) | 81-53 | Won | -1.0870 | -0.0000 |
| 31-Dec-05 | vs Chicago St (228) | 86-69 | Won | -0.7664 | -0.0000 |
| 03-Jan-06 | at Indiana (29) | 63-70 | Lost | 1.4808 | -0.5802 |
| 07-Jan-06 | vs Purdue (148) | 68-65 | Won | -0.2250 | -0.0000 |
| 14-Jan-06 | at Illinois (9) | 74-79 | Lost | 1.8854 | -0.1756 |
| 18-Jan-06 | vs Northwestern (86) | 68-51 | Won | 0.2218 | 0.1607 |
| 21-Jan-06 | at Minnesota (70) | 71-55 | Won | 1.0235 | 0.9625 |
| 25-Jan-06 | vs Michigan St (30) | 72-67 | Won | 0.7657 | 0.7047 |
| 28-Jan-06 | vs Wisconsin (37) | 85-76 | Won | 0.6846 | 0.6235 |
| 01-Feb-06 | at Penn St (94) | 71-65 | Won | 0.8648 | 0.8038 |
| 04-Feb-06 | at Iowa (17) | 66-94 | Lost | 1.7251 | -0.3359 |
| 09-Feb-06 | vs Ohio State (11) | 85-94 | Lost | 1.1562 | -0.9048 |
| 11-Feb-06 | at Purdue (148) | 70-84 | Lost | 0.4687 | -1.0000 |
| 15-Feb-06 | vs Minnesota (70) | 72-50 | Won | 0.3297 | 0.2687 |
| 18-Feb-06 | at Michigan St (30) | 71-90 | Lost | 1.4595 | -0.6015 |
| 21-Feb-06 | vs Illinois (9) | 72-64 | Won | 1.1917 | 1.0000 |
| 25-Feb-06 | at Ohio State (11) | 54-64 | Lost | 1.8499 | -0.2111 |
| 04-Mar-06 | vs Indiana (29) | 67-69 | Lost | 0.7870 | -1.0000 |
| 09-Mar-06 | vs Minnesota (70) | 55-59 | Lost | 0.6766 | -1.0000 |
| 16-Mar-06 | vs UTEP (98) | 82-67 | Won | 0.1456 | 0.0846 |
| 20-Mar-06 | vs Notre Dame (64) | 87-84 | Won | 0.4045 | 0.3435 |
| 22-Mar-06 | vs Miami FL (67) | 71-65 | Won | 0.3683 | 0.3073 |
| 28-Mar-06 | vs Old Dominion (56) | 66-43 | Won | 0.8328 | 0.7718 |
| 30-Mar-06 | at South Carolina (43) | 64-76 | Lost | 0.9798 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3469).