| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Nicholls St (283) | 99-65 | Won | -1.1058 | -0.0000 |
| 21-Nov-05 | vs Florida A&M (262) | 100-63 | Won | -1.0152 | -0.0000 |
| 26-Nov-05 | at Western Illinois (310) | 102-79 | Won | -0.8867 | -0.0000 |
| 30-Nov-05 | vs Duke (1) | 67-75 | Lost | 1.6935 | -0.4404 |
| 03-Dec-05 | vs Eastern Michigan (276) | 79-63 | Won | -1.0788 | -0.0000 |
| 06-Dec-05 | at Indiana St (136) | 67-72 | Lost | 0.5565 | -1.0000 |
| 10-Dec-05 | vs Kentucky (27) | 79-53 | Won | 1.1574 | 1.0000 |
| 19-Dec-05 | at Charlotte (91) | 71-54 | Won | 0.8855 | 0.7516 |
| 23-Dec-05 | at Butler (88) | 73-55 | Won | 0.5613 | 0.4274 |
| 31-Dec-05 | at Ball St (209) | 80-56 | Won | 0.0341 | -0.0000 |
| 03-Jan-06 | vs Michigan (33) | 70-63 | Won | 0.7141 | 0.5802 |
| 07-Jan-06 | vs Ohio State (11) | 81-79 | Won | 1.1562 | 1.0000 |
| 11-Jan-06 | at Michigan St (30) | 73-87 | Lost | 1.4595 | -0.6744 |
| 17-Jan-06 | vs Illinois (9) | 62-60 | Won | 1.1917 | 1.0000 |
| 21-Jan-06 | vs Purdue (148) | 62-49 | Won | -0.2250 | -0.0000 |
| 24-Jan-06 | at Iowa (17) | 60-73 | Lost | 1.7251 | -0.4088 |
| 29-Jan-06 | at Minnesota (70) | 42-61 | Lost | 1.0235 | -1.0000 |
| 01-Feb-06 | vs Northwestern (86) | 72-63 | Won | 0.2218 | 0.0878 |
| 04-Feb-06 | vs Connecticut (2) | 80-88 | Lost | 1.6735 | -0.4604 |
| 08-Feb-06 | at Wisconsin (37) | 54-72 | Lost | 1.3783 | -0.7556 |
| 11-Feb-06 | vs Iowa (17) | 67-70 | Lost | 1.0314 | -1.0000 |
| 15-Feb-06 | at Penn St (94) | 68-71 | Lost | 0.8648 | -1.0000 |
| 19-Feb-06 | at Illinois (9) | 58-70 | Lost | 1.8854 | -0.2485 |
| 22-Feb-06 | vs Penn St (94) | 69-65 | Won | 0.1710 | 0.0371 |
| 26-Feb-06 | vs Michigan St (30) | 78-71 | Won | 0.7657 | 0.6318 |
| 01-Mar-06 | at Purdue (148) | 70-59 | Won | 0.4687 | 0.3348 |
| 04-Mar-06 | at Michigan (33) | 69-67 | Won | 1.4079 | 1.0000 |
| 10-Mar-06 | at Wisconsin (37) | 61-56 | Won | 1.0315 | 0.8975 |
| 11-Mar-06 | vs Ohio State (11) | 51-52 | Lost | 1.5031 | -0.6309 |
| 16-Mar-06 | vs San Diego St (69) | 87-83 | Won | 0.6826 | 0.5487 |
| 18-Mar-06 | at Gonzaga (12) | 80-90 | Lost | 1.4761 | -0.6578 |
A red opponent rating indicates modification according to home court advantage (0.3469).