| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | at Hawai`i (105) | 62-84 | Lost | 0.7889 | -1.0000 |
| 22-Nov-05 | vs Gonzaga (12) | 106-109 | Lost | 1.4761 | -0.6365 |
| 23-Nov-05 | vs Arizona (42) | 74-71 | Won | 0.9905 | 0.8779 |
| 27-Nov-05 | vs IPFW (275) | 84-73 | Won | -1.0772 | -0.0000 |
| 30-Nov-05 | vs Georgia Tech (124) | 88-86 | Won | -0.0898 | -0.0000 |
| 03-Dec-05 | vs Arkansas-Little Rock (200) | 72-67 | Won | -0.2490 | -0.0000 |
| 06-Dec-05 | vs Boston College (19) | 77-70 | Won | 1.3571 | 1.0000 |
| 10-Dec-05 | vs Wichita St (31) | 83-64 | Won | 1.1000 | 0.9874 |
| 16-Dec-05 | vs Cleveland St (241) | 83-75 | Won | -0.8312 | -0.0000 |
| 18-Dec-05 | vs Florida Int'l (268) | 85-58 | Won | -1.0475 | -0.0000 |
| 21-Dec-05 | at UW-Green Bay (158) | 98-69 | Won | 0.3930 | 0.2804 |
| 28-Dec-05 | vs Tennessee Tech (150) | 80-63 | Won | -0.2294 | -0.0000 |
| 31-Dec-05 | vs Coppin St (279) | 78-54 | Won | -1.0870 | -0.0000 |
| 05-Jan-06 | at Illinois (9) | 50-60 | Lost | 1.8854 | -0.2272 |
| 08-Jan-06 | at Wisconsin (37) | 63-82 | Lost | 1.3783 | -0.7343 |
| 11-Jan-06 | vs Indiana (29) | 87-73 | Won | 0.7870 | 0.6744 |
| 15-Jan-06 | at Ohio State (11) | 62-59 | Won | 1.8499 | 1.0000 |
| 21-Jan-06 | vs Iowa (17) | 85-55 | Won | 1.0314 | 0.9188 |
| 25-Jan-06 | at Michigan (33) | 67-72 | Lost | 1.4079 | -0.7047 |
| 28-Jan-06 | vs Penn St (94) | 69-60 | Won | 0.1710 | 0.0584 |
| 04-Feb-06 | at Northwestern (86) | 77-66 | Won | 0.9155 | 0.8030 |
| 08-Feb-06 | vs Purdue (148) | 77-52 | Won | -0.2250 | -0.0000 |
| 11-Feb-06 | at Minnesota (70) | 55-69 | Lost | 1.0235 | -1.0000 |
| 14-Feb-06 | at Iowa (17) | 54-66 | Lost | 1.7251 | -0.3874 |
| 18-Feb-06 | vs Michigan (33) | 90-71 | Won | 0.7141 | 0.6015 |
| 22-Feb-06 | vs Ohio State (11) | 68-79 | Lost | 1.1562 | -0.9564 |
| 26-Feb-06 | at Indiana (29) | 71-78 | Lost | 1.4808 | -0.6318 |
| 02-Mar-06 | vs Wisconsin (37) | 74-65 | Won | 0.6846 | 0.5720 |
| 04-Mar-06 | vs Illinois (9) | 68-75 | Lost | 1.1917 | -0.9209 |
| 09-Mar-06 | vs Purdue (148) | 70-58 | Won | 0.1218 | 0.0093 |
| 10-Mar-06 | at Illinois (9) | 61-56 | Won | 1.5385 | 1.0000 |
| 11-Mar-06 | at Iowa (17) | 48-53 | Lost | 1.3783 | -0.7343 |
| 17-Mar-06 | vs George Mason (20) | 65-75 | Lost | 1.2827 | -0.8298 |
A red opponent rating indicates modification according to home court advantage (0.3469).