| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 14-Nov-05 | vs MD-Eastern Shore (318) | 86-41 | Won | -1.6570 | -0.0000 |
| 15-Nov-05 | vs Colgate (297) | 73-51 | Won | -1.2958 | -0.0000 |
| 21-Nov-05 | at Kentucky (27) | 67-63 | Won | 1.1574 | 0.7792 |
| 22-Nov-05 | at Texas (10) | 59-68 | Lost | 1.5371 | -0.8411 |
| 26-Nov-05 | vs Texas-San Antonio (249) | 79-46 | Won | -0.8933 | -0.0000 |
| 30-Nov-05 | vs North Carolina St (25) | 45-42 | Won | 0.8537 | 0.4754 |
| 02-Dec-05 | vs Fairfield (204) | 75-59 | Won | -0.6211 | -0.0000 |
| 03-Dec-05 | vs Valparaiso (194) | 72-59 | Won | -0.5545 | -0.0000 |
| 06-Dec-05 | at Northern Iowa (41) | 63-67 | Lost | 1.3470 | -1.0000 |
| 09-Dec-05 | at Iowa St (99) | 60-72 | Lost | 0.8326 | -1.0000 |
| 17-Dec-05 | vs Arizona St (159) | 62-43 | Won | -0.3026 | -0.0000 |
| 20-Dec-05 | vs Drake (162) | 65-60 | Won | -0.3417 | -0.0000 |
| 22-Dec-05 | vs Robert Morris PA (250) | 73-51 | Won | -0.9057 | -0.0000 |
| 30-Dec-05 | at St Louis (106) | 60-50 | Won | 0.7613 | 0.3831 |
| 05-Jan-06 | at Wisconsin (37) | 52-66 | Lost | 1.3783 | -0.9999 |
| 07-Jan-06 | vs Illinois (9) | 63-48 | Won | 1.1917 | 0.8134 |
| 14-Jan-06 | at Penn St (94) | 80-76 | Won | 0.8648 | 0.4865 |
| 18-Jan-06 | vs Minnesota (70) | 76-72 | Won | 0.3297 | -0.0000 |
| 21-Jan-06 | at Michigan St (30) | 55-85 | Lost | 1.4595 | -0.9188 |
| 24-Jan-06 | vs Indiana (29) | 73-60 | Won | 0.7870 | 0.4088 |
| 28-Jan-06 | vs Ohio State (11) | 67-62 | Won | 1.1562 | 0.7779 |
| 01-Feb-06 | at Purdue (148) | 77-68 | Won | 0.4687 | 0.0905 |
| 04-Feb-06 | vs Michigan (33) | 94-66 | Won | 0.7141 | 0.3359 |
| 08-Feb-06 | at Northwestern (86) | 48-51 | Lost | 0.9155 | -1.0000 |
| 11-Feb-06 | at Indiana (29) | 70-67 | Won | 1.4808 | 1.0000 |
| 14-Feb-06 | vs Michigan St (30) | 66-54 | Won | 0.7657 | 0.3874 |
| 18-Feb-06 | at Minnesota (70) | 61-74 | Lost | 1.0235 | -1.0000 |
| 25-Feb-06 | at Illinois (9) | 59-71 | Lost | 1.8854 | -0.4928 |
| 01-Mar-06 | vs Penn St (94) | 65-38 | Won | 0.1710 | -0.0000 |
| 04-Mar-06 | vs Wisconsin (37) | 59-44 | Won | 0.6846 | 0.3063 |
| 10-Mar-06 | vs Minnesota (70) | 67-57 | Won | 0.6766 | 0.2983 |
| 11-Mar-06 | vs Michigan St (30) | 53-48 | Won | 1.1126 | 0.7343 |
| 12-Mar-06 | at Ohio State (11) | 67-60 | Won | 1.5031 | 1.0000 |
| 17-Mar-06 | vs Northwestern St (66) | 63-64 | Lost | 0.7316 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3469).