| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Cornell NY (245) | 66-54 | Won | -0.8515 | -0.0000 |
| 23-Nov-05 | vs Nicholls St (283) | 93-56 | Won | -1.1058 | -0.0000 |
| 26-Nov-05 | vs LIU-Brooklyn (284) | 80-64 | Won | -1.1095 | -0.0000 |
| 29-Nov-05 | vs Clemson (62) | 88-96 | Lost | 0.4163 | -1.0000 |
| 03-Dec-05 | at Texas A&M (40) | 55-60 | Lost | 1.3506 | -0.1673 |
| 07-Dec-05 | vs UMKC (240) | 75-71 | Won | -0.8305 | -0.0000 |
| 10-Dec-05 | at Pittsburgh (13) | 54-91 | Lost | 1.8114 | 0.0000 |
| 18-Dec-05 | vs St Francis PA (327) | 88-74 | Won | -1.9389 | -0.0000 |
| 20-Dec-05 | vs New Hampshire (274) | 75-51 | Won | -1.0755 | -0.0000 |
| 28-Dec-05 | vs IPFW (275) | 74-59 | Won | -1.0772 | -0.0000 |
| 31-Dec-05 | vs Mt St Mary's MD (252) | 65-53 | Won | -0.9118 | -0.0000 |
| 05-Jan-06 | at Ohio State (11) | 69-104 | Lost | 1.8499 | 0.0000 |
| 11-Jan-06 | at Northwestern (86) | 65-61 | Won | 0.9155 | 1.0000 |
| 14-Jan-06 | vs Iowa (17) | 76-80 | Lost | 1.0314 | -0.4865 |
| 18-Jan-06 | vs Purdue (148) | 74-54 | Won | -0.2250 | 0.2571 |
| 21-Jan-06 | vs Ohio State (11) | 64-75 | Lost | 1.1562 | -0.3617 |
| 25-Jan-06 | at Wisconsin (37) | 43-72 | Lost | 1.3783 | -0.1396 |
| 28-Jan-06 | at Michigan St (30) | 60-69 | Lost | 1.4595 | -0.0584 |
| 01-Feb-06 | vs Michigan (33) | 65-71 | Lost | 0.7141 | -0.8038 |
| 04-Feb-06 | at Illinois (9) | 66-65 | Won | 1.8854 | 1.0000 |
| 08-Feb-06 | vs Minnesota (70) | 66-77 | Lost | 0.3297 | -1.0000 |
| 11-Feb-06 | vs Wisconsin (37) | 62-82 | Lost | 0.6846 | -0.8333 |
| 15-Feb-06 | vs Indiana (29) | 71-68 | Won | 0.7870 | 1.0000 |
| 18-Feb-06 | at Purdue (148) | 69-61 | Won | 0.4687 | 0.9508 |
| 22-Feb-06 | at Indiana (29) | 65-69 | Lost | 1.4808 | -0.0371 |
| 25-Feb-06 | vs Northwestern (86) | 68-55 | Won | 0.2218 | 0.7039 |
| 01-Mar-06 | at Iowa (17) | 38-65 | Lost | 1.7251 | 0.0000 |
| 09-Mar-06 | vs Northwestern (86) | 60-42 | Won | 0.5687 | 1.0000 |
| 10-Mar-06 | at Ohio State (11) | 56-63 | Lost | 1.5031 | -0.0148 |
| 14-Mar-06 | vs Rutgers (54) | 71-76 | Lost | 0.4933 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3469).