| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 20-Nov-05 | vs Austin Peay (175) | 66-46 | Won | -0.4364 | -0.0000 |
| 22-Nov-05 | vs Delaware St (151) | 49-42 | Won | -0.2342 | -0.0000 |
| 25-Nov-05 | at Kent St (53) | 55-52 | Won | 0.8416 | 1.0000 |
| 26-Nov-05 | at Illinois (9) | 57-77 | Lost | 1.5385 | -0.3016 |
| 30-Nov-05 | vs Temple (78) | 67-53 | Won | 0.2947 | 0.4545 |
| 03-Dec-05 | at St Mary's CA (110) | 75-69 | Won | 0.7237 | 0.8835 |
| 07-Dec-05 | vs MD-Eastern Shore (318) | 92-50 | Won | -1.6570 | -0.0000 |
| 10-Dec-05 | at Buffalo (116) | 53-62 | Lost | 0.6598 | -1.0000 |
| 15-Dec-05 | vs Maine (289) | 91-56 | Won | -1.1581 | -0.0000 |
| 17-Dec-05 | vs South Carolina St (226) | 63-45 | Won | -0.7536 | -0.0000 |
| 22-Dec-05 | vs Charlotte (91) | 82-85 | Lost | 0.1917 | -1.0000 |
| 31-Dec-05 | vs Princeton (219) | 54-44 | Won | -0.7049 | -0.0000 |
| 07-Jan-06 | vs Seton Hall (59) | 82-78 | Won | 0.4627 | 0.6226 |
| 11-Jan-06 | vs Villanova (3) | 78-84 | Lost | 1.5125 | -0.3277 |
| 15-Jan-06 | at DePaul (79) | 78-68 | Won | 0.9821 | 1.0000 |
| 18-Jan-06 | vs Pittsburgh (13) | 68-76 | Lost | 1.1176 | -0.7226 |
| 22-Jan-06 | at Cincinnati (45) | 66-71 | Lost | 1.3058 | -0.5343 |
| 25-Jan-06 | vs Providence RI (93) | 69-79 | Lost | 0.1796 | -1.0000 |
| 28-Jan-06 | vs Louisville (52) | 65-56 | Won | 0.5394 | 0.6992 |
| 01-Feb-06 | at Syracuse (23) | 84-86 | Lost | 1.5803 | -0.2599 |
| 05-Feb-06 | at Seton Hall (59) | 67-73 | Lost | 1.1565 | -0.6837 |
| 08-Feb-06 | at Notre Dame (64) | 63-90 | Lost | 1.0983 | -0.7419 |
| 12-Feb-06 | vs Marquette (36) | 91-84 | Won | 0.6985 | 0.8583 |
| 15-Feb-06 | vs St John's NY (119) | 51-54 | Lost | -0.0615 | -1.0000 |
| 18-Feb-06 | at South Florida (230) | 65-51 | Won | -0.0819 | 0.0779 |
| 22-Feb-06 | at Georgetown DC (15) | 50-66 | Lost | 1.7389 | -0.1013 |
| 26-Feb-06 | vs South Florida (230) | 62-44 | Won | -0.7756 | -0.0000 |
| 05-Mar-06 | at St John's NY (119) | 82-70 | Won | 0.6323 | 0.7921 |
| 08-Mar-06 | at Seton Hall (59) | 61-48 | Won | 0.8096 | 0.9694 |
| 09-Mar-06 | at Villanova (3) | 55-87 | Lost | 1.8594 | 0.0000 |
| 14-Mar-06 | at Penn St (94) | 76-71 | Won | 0.8648 | 1.0000 |
| 16-Mar-06 | at St Joseph's PA (58) | 62-71 | Lost | 1.1705 | -0.6697 |
A red opponent rating indicates modification according to home court advantage (0.3469).