| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Lafayette (269) | 70-47 | Won | -1.0593 | -0.0000 |
| 21-Nov-05 | at Fairfield (204) | 72-41 | Won | 0.0727 | 0.2490 |
| 26-Nov-05 | at Davidson (118) | 94-100 | Lost | 0.6474 | -1.0000 |
| 29-Nov-05 | vs Drexel (132) | 69-59 | Won | 0.2372 | 0.4136 |
| 06-Dec-05 | at Kansas (21) | 70-67 | Won | 1.2657 | 1.0000 |
| 10-Dec-05 | vs Ohio State (11) | 74-81 | Lost | 1.1562 | -0.6675 |
| 21-Dec-05 | at Bucknell (22) | 51-63 | Lost | 1.6046 | -0.2191 |
| 28-Dec-05 | at St Mary's CA (110) | 70-66 | Won | 0.7237 | 0.9000 |
| 31-Dec-05 | at Gonzaga (12) | 94-102 | Lost | 1.8230 | -0.0007 |
| 04-Jan-06 | vs Xavier OH (71) | 58-62 | Lost | 0.3275 | -1.0000 |
| 08-Jan-06 | vs Temple (78) | 59-57 | Won | 0.2947 | 0.4710 |
| 11-Jan-06 | at Massachusetts (125) | 58-68 | Lost | 0.6029 | -1.0000 |
| 14-Jan-06 | at George Washington (8) | 70-82 | Lost | 1.9179 | 0.0000 |
| 17-Jan-06 | vs Charlotte (91) | 50-57 | Lost | 0.1917 | -1.0000 |
| 21-Jan-06 | vs La Salle (103) | 66-54 | Won | 0.4625 | 0.6388 |
| 25-Jan-06 | at St Louis (106) | 54-39 | Won | 0.7613 | 0.9377 |
| 28-Jan-06 | at Pennsylvania (121) | 47-44 | Won | 0.2726 | 0.4489 |
| 01-Feb-06 | at Dayton (161) | 69-77 | Lost | 0.3622 | -1.0000 |
| 04-Feb-06 | at St Bonaventure (244) | 82-51 | Won | -0.1552 | 0.0212 |
| 07-Feb-06 | at Villanova (3) | 58-71 | Lost | 1.8594 | 0.0000 |
| 11-Feb-06 | vs George Washington (8) | 62-64 | Lost | 1.2241 | -0.5996 |
| 14-Feb-06 | at Temple (78) | 44-57 | Lost | 0.9885 | -0.8352 |
| 18-Feb-06 | at Rhode Island (141) | 57-55 | Won | 0.5208 | 0.6972 |
| 22-Feb-06 | vs Fordham (127) | 64-58 | Won | -0.0971 | 0.0793 |
| 25-Feb-06 | vs Richmond (176) | 70-39 | Won | -0.4396 | -0.0000 |
| 28-Feb-06 | at Xavier OH (71) | 68-58 | Won | 1.0213 | 1.0000 |
| 04-Mar-06 | at Duquesne (317) | 79-63 | Won | -0.9509 | -0.0000 |
| 08-Mar-06 | vs Dayton (161) | 67-55 | Won | 0.0153 | 0.1917 |
| 09-Mar-06 | at St Louis (106) | 56-37 | Won | 0.4145 | 0.5908 |
| 10-Mar-06 | vs Temple (78) | 73-59 | Won | 0.6416 | 0.8179 |
| 11-Mar-06 | at Xavier OH (71) | 61-62 | Lost | 1.0213 | -0.8023 |
| 16-Mar-06 | vs Rutgers (54) | 71-62 | Won | 0.4933 | 0.6697 |
| 20-Mar-06 | vs Hofstra (26) | 75-77 | Lost | 0.8357 | -0.9880 |
A red opponent rating indicates modification according to home court advantage (0.3469).