| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Stony Brook (319) | 78-35 | Won | -1.7471 | -0.0000 |
| 27-Nov-05 | vs Lehigh (172) | 84-47 | Won | -0.4002 | -0.0000 |
| 30-Nov-05 | vs Rider (224) | 86-57 | Won | -0.3744 | -0.0000 |
| 03-Dec-05 | vs Oklahoma (46) | 85-74 | Won | 0.6064 | -0.0000 |
| 06-Dec-05 | at Bucknell (22) | 79-60 | Won | 1.6046 | 0.7452 |
| 10-Dec-05 | vs Longwood (303) | 90-77 | Won | -1.0577 | -0.0000 |
| 13-Dec-05 | at Pennsylvania (121) | 62-55 | Won | 0.6195 | -0.0000 |
| 22-Dec-05 | vs La Salle (103) | 98-57 | Won | 0.1156 | -0.0000 |
| 31-Dec-05 | at Temple (78) | 75-53 | Won | 0.6416 | -0.0000 |
| 05-Jan-06 | at Louisville (52) | 76-67 | Won | 1.2331 | 0.3738 |
| 08-Jan-06 | vs West Virginia (24) | 87-91 | Lost | 0.8724 | -1.0000 |
| 11-Jan-06 | at Rutgers (54) | 84-78 | Won | 1.1871 | 0.3277 |
| 14-Jan-06 | at Texas (10) | 55-58 | Lost | 1.8840 | -0.9754 |
| 17-Jan-06 | vs Seton Hall (59) | 73-64 | Won | 0.4627 | -0.0000 |
| 21-Jan-06 | vs Syracuse (23) | 80-65 | Won | 0.8865 | 0.0271 |
| 24-Jan-06 | at South Florida (230) | 49-46 | Won | -0.0819 | -0.0000 |
| 28-Jan-06 | at Notre Dame (64) | 72-70 | Won | 1.0983 | 0.2389 |
| 30-Jan-06 | vs Louisville (52) | 79-73 | Won | 0.5394 | -0.0000 |
| 04-Feb-06 | vs Marquette (36) | 72-67 | Won | 0.6985 | -0.0000 |
| 07-Feb-06 | vs St Joseph's PA (58) | 71-58 | Won | 0.8236 | -0.0000 |
| 11-Feb-06 | at DePaul (79) | 61-51 | Won | 0.9821 | 0.1227 |
| 13-Feb-06 | vs Connecticut (2) | 69-64 | Won | 1.6735 | 0.8142 |
| 19-Feb-06 | vs Georgetown DC (15) | 75-65 | Won | 1.0451 | 0.1858 |
| 23-Feb-06 | at Cincinnati (45) | 74-72 | Won | 1.3058 | 0.4465 |
| 26-Feb-06 | at Connecticut (2) | 75-89 | Lost | 2.3673 | -0.4921 |
| 01-Mar-06 | vs St John's NY (119) | 65-52 | Won | -0.0615 | -0.0000 |
| 05-Mar-06 | at Syracuse (23) | 92-82 | Won | 1.5803 | 0.7209 |
| 09-Mar-06 | vs Rutgers (54) | 87-55 | Won | 0.8402 | -0.0000 |
| 10-Mar-06 | vs Pittsburgh (13) | 54-68 | Lost | 1.4645 | -1.0000 |
| 17-Mar-06 | vs Monmouth NJ (181) | 58-45 | Won | -0.4610 | -0.0000 |
| 19-Mar-06 | vs Arizona (42) | 82-78 | Won | 0.6436 | -0.0000 |
| 24-Mar-06 | vs Boston College (19) | 60-59 | Won | 1.3571 | 0.4977 |
| 26-Mar-06 | at Florida (4) | 62-75 | Lost | 1.8485 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3469).