| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Bradley (38) | 60-75 | Lost | 0.6806 | -0.9546 |
| 26-Nov-05 | vs Northwestern (86) | 59-49 | Won | 0.2218 | 0.5866 |
| 28-Nov-05 | at Northern Illinois (115) | 68-77 | Lost | 0.6831 | -0.9521 |
| 30-Nov-05 | vs Creighton (49) | 72-57 | Won | 0.5534 | 0.9182 |
| 03-Dec-05 | vs Bucknell (22) | 52-57 | Lost | 0.9108 | -0.7244 |
| 06-Dec-05 | vs Alabama-Birmingham (50) | 70-66 | Won | 0.5467 | 0.9115 |
| 10-Dec-05 | at Dayton (161) | 61-54 | Won | 0.3622 | 0.7270 |
| 13-Dec-05 | at Wake Forest (77) | 84-81 | Won | 0.9892 | 1.0000 |
| 17-Dec-05 | at Old Dominion (56) | 43-87 | Lost | 1.1797 | -0.4555 |
| 21-Dec-05 | at California (39) | 68-65 | Won | 1.3576 | 1.0000 |
| 31-Dec-05 | vs Florida Int'l (268) | 72-60 | Won | -1.0475 | -0.0000 |
| 04-Jan-06 | at Cincinnati (45) | 60-82 | Lost | 1.3058 | -0.3293 |
| 07-Jan-06 | vs Notre Dame (64) | 73-67 | Won | 0.4045 | 0.7693 |
| 12-Jan-06 | at Pittsburgh (13) | 65-73 | Lost | 1.8114 | 0.0000 |
| 15-Jan-06 | vs Rutgers (54) | 68-78 | Lost | 0.4933 | -1.0000 |
| 17-Jan-06 | vs Marquette (36) | 79-82 | Lost | 0.6985 | -0.9367 |
| 21-Jan-06 | at Providence RI (93) | 75-76 | Lost | 0.8734 | -0.7618 |
| 25-Jan-06 | at Marquette (36) | 47-62 | Lost | 1.3923 | -0.2429 |
| 31-Jan-06 | vs Georgetown DC (15) | 44-64 | Lost | 1.0451 | -0.5900 |
| 03-Feb-06 | at South Florida (230) | 80-66 | Won | -0.0819 | 0.2829 |
| 07-Feb-06 | vs Providence RI (93) | 60-61 | Lost | 0.1796 | -1.0000 |
| 11-Feb-06 | vs Villanova (3) | 51-61 | Lost | 1.5125 | -0.1227 |
| 18-Feb-06 | at St John's NY (119) | 52-48 | Won | 0.6323 | 0.9971 |
| 22-Feb-06 | at Louisville (52) | 53-65 | Lost | 1.2331 | -0.4021 |
| 25-Feb-06 | vs Seton Hall (59) | 67-64 | Won | 0.4627 | 0.8276 |
| 02-Mar-06 | vs Syracuse (23) | 108-69 | Won | 0.8865 | 1.0000 |
| 04-Mar-06 | at Notre Dame (64) | 61-66 | Lost | 1.0983 | -0.5369 |
A red opponent rating indicates modification according to home court advantage (0.3469).