| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | at Navy (295) | 72-49 | Won | -0.5705 | -0.0000 |
| 21-Nov-05 | at James Madison (293) | 73-66 | Won | -0.5540 | -0.0000 |
| 26-Nov-05 | vs Vanderbilt (61) | 61-68 | Lost | 0.4424 | -1.0000 |
| 03-Dec-05 | at Oregon (111) | 71-57 | Won | 0.7164 | 0.3243 |
| 08-Dec-05 | at Illinois (9) | 48-58 | Lost | 1.8854 | -0.5066 |
| 11-Dec-05 | vs Fairfield (204) | 76-51 | Won | -0.6211 | -0.0000 |
| 17-Dec-05 | vs Stetson (298) | 70-50 | Won | -1.3298 | -0.0000 |
| 21-Dec-05 | vs Savannah St (334) | 78-49 | Won | -2.8093 | -0.0000 |
| 27-Dec-05 | at Colgate (297) | 61-45 | Won | -0.9490 | -0.0000 |
| 28-Dec-05 | at UTEP (98) | 76-64 | Won | 0.8394 | 0.4474 |
| 05-Jan-06 | vs Providence RI (93) | 72-62 | Won | 0.1796 | -0.0000 |
| 08-Jan-06 | at St John's NY (119) | 79-65 | Won | 0.6323 | 0.2402 |
| 11-Jan-06 | at West Virginia (24) | 61-68 | Lost | 1.5662 | -0.8259 |
| 14-Jan-06 | at Connecticut (2) | 67-74 | Lost | 2.3673 | -0.0247 |
| 17-Jan-06 | vs South Florida (230) | 50-47 | Won | -0.7756 | -0.0000 |
| 21-Jan-06 | vs Duke (1) | 87-84 | Won | 1.6935 | 1.0000 |
| 24-Jan-06 | at Notre Dame (64) | 85-82 | Won | 1.0983 | 0.7062 |
| 28-Jan-06 | vs Cincinnati (45) | 76-57 | Won | 0.6121 | 0.2200 |
| 31-Jan-06 | at DePaul (79) | 64-44 | Won | 0.9821 | 0.5900 |
| 05-Feb-06 | vs Pittsburgh (13) | 61-58 | Won | 1.1176 | 0.7256 |
| 09-Feb-06 | vs St John's NY (119) | 64-41 | Won | -0.0615 | -0.0000 |
| 12-Feb-06 | vs West Virginia (24) | 56-69 | Lost | 0.8724 | -1.0000 |
| 16-Feb-06 | at Marquette (36) | 51-57 | Lost | 1.3923 | -0.9997 |
| 19-Feb-06 | at Villanova (3) | 65-75 | Lost | 2.2063 | -0.1858 |
| 22-Feb-06 | vs Rutgers (54) | 66-50 | Won | 0.4933 | 0.1013 |
| 25-Feb-06 | vs Syracuse (23) | 68-53 | Won | 0.8865 | 0.4945 |
| 04-Mar-06 | at South Florida (230) | 56-63 | Lost | -0.0819 | -1.0000 |
| 09-Mar-06 | at Marquette (36) | 62-59 | Won | 1.0454 | 0.6534 |
| 10-Mar-06 | vs Syracuse (23) | 57-58 | Lost | 1.2334 | -1.0000 |
| 17-Mar-06 | vs Northern Iowa (41) | 54-49 | Won | 1.0001 | 0.6081 |
| 19-Mar-06 | at Ohio State (11) | 70-52 | Won | 1.5031 | 1.0000 |
| 24-Mar-06 | at Florida (4) | 53-57 | Lost | 1.8485 | -0.5436 |
A red opponent rating indicates modification according to home court advantage (0.3469).