| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 12-Nov-05 | vs Louisiana-Monroe (254) | 88-69 | Won | -0.9189 | -0.0000 |
| 13-Nov-05 | vs Wofford (271) | 61-41 | Won | -1.0656 | -0.0000 |
| 21-Nov-05 | at Texas (10) | 75-76 | Lost | 1.5371 | -0.6822 |
| 22-Nov-05 | vs Kentucky (27) | 66-80 | Lost | 1.1574 | -1.0000 |
| 26-Nov-05 | vs LSU (6) | 68-71 | Lost | 1.2778 | -0.9415 |
| 30-Nov-05 | at St Bonaventure (244) | 66-61 | Won | -0.5021 | -0.0000 |
| 07-Dec-05 | vs MD-Baltimore County (282) | 82-53 | Won | -1.1045 | -0.0000 |
| 10-Dec-05 | vs Duquesne (317) | 86-66 | Won | -1.6447 | -0.0000 |
| 22-Dec-05 | at Oklahoma (46) | 92-68 | Won | 0.9533 | 0.7340 |
| 30-Dec-05 | vs Canisius (246) | 80-68 | Won | -0.8525 | -0.0000 |
| 05-Jan-06 | at South Florida (230) | 57-53 | Won | -0.0819 | -0.0000 |
| 08-Jan-06 | at Villanova (3) | 91-87 | Won | 2.2063 | 1.0000 |
| 11-Jan-06 | vs Georgetown DC (15) | 68-61 | Won | 1.0451 | 0.8259 |
| 14-Jan-06 | vs Marquette (36) | 104-85 | Won | 0.6985 | 0.4792 |
| 17-Jan-06 | vs Providence RI (93) | 64-48 | Won | 0.1796 | -0.0000 |
| 21-Jan-06 | at UCLA (7) | 60-56 | Won | 1.9572 | 1.0000 |
| 25-Jan-06 | vs Marshall (231) | 52-58 | Lost | -0.4318 | -1.0000 |
| 29-Jan-06 | at St John's NY (119) | 66-61 | Won | 0.6323 | 0.4130 |
| 01-Feb-06 | vs Notre Dame (64) | 71-70 | Won | 0.4045 | 0.1852 |
| 04-Feb-06 | vs Cincinnati (45) | 66-57 | Won | 0.6121 | 0.3928 |
| 09-Feb-06 | at Pittsburgh (13) | 53-57 | Lost | 1.8114 | -0.4079 |
| 12-Feb-06 | at Georgetown DC (15) | 69-56 | Won | 1.7389 | 1.0000 |
| 14-Feb-06 | at Seton Hall (59) | 64-71 | Lost | 1.1565 | -1.0000 |
| 18-Feb-06 | vs Connecticut (2) | 75-81 | Lost | 1.6735 | -0.5457 |
| 20-Feb-06 | at Syracuse (23) | 58-60 | Lost | 1.5803 | -0.6390 |
| 25-Feb-06 | vs Louisville (52) | 68-64 | Won | 0.5394 | 0.3201 |
| 27-Feb-06 | vs Pittsburgh (13) | 67-62 | Won | 1.1176 | 0.8983 |
| 04-Mar-06 | at Cincinnati (45) | 75-78 | Lost | 1.3058 | -0.9134 |
| 09-Mar-06 | vs Pittsburgh (13) | 57-68 | Lost | 1.4645 | -0.7548 |
| 17-Mar-06 | vs Southern Illinois (35) | 64-46 | Won | 1.0467 | 0.8274 |
| 19-Mar-06 | vs Northwestern St (66) | 67-54 | Won | 0.7316 | 0.5124 |
| 23-Mar-06 | at Texas (10) | 71-74 | Lost | 1.5371 | -0.6822 |
A red opponent rating indicates modification according to home court advantage (0.3469).