| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Eastern Illinois (301) | 80-35 | Won | -1.3711 | -0.0000 |
| 26-Nov-05 | at Purdue (148) | 74-55 | Won | 0.1218 | 0.4474 |
| 29-Nov-05 | vs Coppin St (279) | 81-56 | Won | -1.0870 | -0.0000 |
| 03-Dec-05 | at Illinois (9) | 62-65 | Lost | 1.5385 | -0.1359 |
| 07-Dec-05 | vs Florida A&M (262) | 79-51 | Won | -1.0152 | -0.0000 |
| 11-Dec-05 | at Miami OH (90) | 75-65 | Won | 0.8887 | 1.0000 |
| 18-Dec-05 | at Creighton (49) | 59-61 | Lost | 1.2472 | -0.4272 |
| 22-Dec-05 | vs Troy (213) | 78-54 | Won | -0.6892 | -0.0000 |
| 29-Dec-05 | vs Southern U. (205) | 73-56 | Won | -0.6408 | -0.0000 |
| 04-Jan-06 | at St Joseph's PA (58) | 62-58 | Won | 1.1705 | 1.0000 |
| 07-Jan-06 | vs St Bonaventure (244) | 99-71 | Won | -0.8490 | -0.0000 |
| 09-Jan-06 | vs Eastern Kentucky (193) | 82-63 | Won | -0.5539 | -0.0000 |
| 14-Jan-06 | at Charlotte (91) | 78-65 | Won | 0.8855 | 1.0000 |
| 19-Jan-06 | vs Cincinnati (45) | 73-71 | Won | 0.6121 | 0.9377 |
| 22-Jan-06 | vs St Louis (106) | 54-59 | Lost | 0.0676 | -1.0000 |
| 25-Jan-06 | at Temple (78) | 79-81 | Lost | 0.9885 | -0.6859 |
| 28-Jan-06 | vs Dayton (161) | 60-55 | Won | -0.3316 | -0.0000 |
| 02-Feb-06 | vs George Washington (8) | 85-89 | Lost | 1.2241 | -0.4503 |
| 05-Feb-06 | at St Louis (106) | 47-61 | Lost | 0.7613 | -0.9131 |
| 08-Feb-06 | at Richmond (176) | 63-51 | Won | 0.2542 | 0.5798 |
| 11-Feb-06 | vs La Salle (103) | 70-79 | Lost | 0.1156 | -1.0000 |
| 15-Feb-06 | vs Fordham (127) | 84-64 | Won | -0.0971 | 0.2285 |
| 18-Feb-06 | vs Duquesne (317) | 91-70 | Won | -1.6447 | -0.0000 |
| 21-Feb-06 | at Dayton (161) | 62-66 | Lost | 0.3622 | -1.0000 |
| 25-Feb-06 | at Rhode Island (141) | 85-76 | Won | 0.5208 | 0.8464 |
| 28-Feb-06 | vs St Joseph's PA (58) | 58-68 | Lost | 0.4768 | -1.0000 |
| 04-Mar-06 | at Massachusetts (125) | 56-65 | Lost | 0.6029 | -1.0000 |
| 08-Mar-06 | vs Massachusetts (125) | 75-66 | Won | -0.0909 | 0.2347 |
| 09-Mar-06 | vs Charlotte (91) | 59-55 | Won | 0.1917 | 0.5173 |
| 10-Mar-06 | vs Fordham (127) | 70-59 | Won | -0.0971 | 0.2285 |
| 11-Mar-06 | vs St Joseph's PA (58) | 62-61 | Won | 0.4768 | 0.8023 |
| 16-Mar-06 | at Gonzaga (12) | 75-79 | Lost | 1.4761 | -0.1983 |
A red opponent rating indicates modification according to home court advantage (0.3469).