| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 13-Nov-05 | at Texas-Arlington (198) | 76-65 | Won | -0.2363 | 0.0485 |
| 14-Nov-05 | at Air Force (60) | 53-57 | Lost | 0.7956 | -0.9196 |
| 15-Nov-05 | at UW-Green Bay (158) | 80-54 | Won | 0.0461 | 0.3309 |
| 19-Nov-05 | vs Morgan St (329) | 83-51 | Won | -2.0721 | -0.0000 |
| 22-Nov-05 | vs North Carolina A&T (320) | 87-62 | Won | -1.7481 | -0.0000 |
| 27-Nov-05 | at Temple (78) | 56-73 | Lost | 0.9885 | -0.7267 |
| 29-Nov-05 | at Michigan (33) | 53-74 | Lost | 1.4079 | -0.3073 |
| 03-Dec-05 | vs Birmingham-Southern (154) | 82-55 | Won | -0.2800 | 0.0048 |
| 10-Dec-05 | vs Wofford (271) | 71-40 | Won | -1.0656 | -0.0000 |
| 18-Dec-05 | at North Carolina St (25) | 69-81 | Lost | 1.5475 | -0.1677 |
| 22-Dec-05 | vs Florida (4) | 67-77 | Lost | 1.5016 | -0.2136 |
| 27-Dec-05 | vs Stetson (298) | 65-56 | Won | -1.3298 | -0.0000 |
| 31-Dec-05 | vs Louisville (52) | 43-58 | Lost | 0.8862 | -0.8289 |
| 02-Jan-06 | vs Sacred Heart (281) | 63-57 | Won | -1.1014 | -0.0000 |
| 07-Jan-06 | vs Maryland (55) | 84-70 | Won | 0.4883 | 0.7731 |
| 14-Jan-06 | at North Carolina (16) | 81-70 | Won | 1.7255 | 1.0000 |
| 18-Jan-06 | vs Clemson (62) | 62-38 | Won | 0.4163 | 0.7011 |
| 21-Jan-06 | vs Boston College (19) | 61-65 | Lost | 1.0102 | -0.7050 |
| 24-Jan-06 | at Virginia (75) | 51-71 | Lost | 0.9989 | -0.7163 |
| 29-Jan-06 | at Florida St (47) | 84-78 | Won | 1.2864 | 1.0000 |
| 31-Jan-06 | vs Wake Forest (77) | 78-69 | Won | 0.2954 | 0.5802 |
| 04-Feb-06 | at Georgia Tech (124) | 70-53 | Won | 0.6040 | 0.8888 |
| 08-Feb-06 | vs North Carolina St (25) | 77-86 | Lost | 0.8537 | -0.8615 |
| 12-Feb-06 | vs North Carolina (16) | 70-80 | Lost | 1.0317 | -0.6834 |
| 16-Feb-06 | at Boston College (19) | 54-65 | Lost | 1.7040 | -0.0112 |
| 19-Feb-06 | at Duke (1) | 71-92 | Lost | 2.3873 | 0.0000 |
| 22-Feb-06 | vs Virginia Tech (117) | 70-59 | Won | -0.0367 | 0.2481 |
| 01-Mar-06 | at Maryland (55) | 61-65 | Lost | 1.1820 | -0.5332 |
| 05-Mar-06 | vs Florida St (47) | 64-67 | Lost | 0.5926 | -1.0000 |
| 09-Mar-06 | vs Clemson (62) | 66-63 | Won | 0.7632 | 1.0000 |
| 10-Mar-06 | at Duke (1) | 76-80 | Lost | 2.0404 | 0.0000 |
| 15-Mar-06 | vs Oklahoma St (102) | 62-59 | Won | 0.1340 | 0.4188 |
| 20-Mar-06 | at Creighton (49) | 53-52 | Won | 1.2472 | 1.0000 |
| 22-Mar-06 | at Michigan (33) | 65-71 | Lost | 1.4079 | -0.3073 |
A red opponent rating indicates modification according to home court advantage (0.3469).