| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 10-Nov-05 | vs Radford (203) | 80-50 | Won | -0.6204 | 0.0695 |
| 12-Nov-05 | vs Bowling Green (256) | 71-72 | Lost | -0.9268 | -1.0000 |
| 13-Nov-05 | vs Western Carolina (233) | 54-40 | Won | -0.7815 | -0.0000 |
| 18-Nov-05 | vs Mt St Mary's MD (252) | 74-62 | Won | -0.9118 | -0.0000 |
| 21-Nov-05 | vs Marshall (231) | 71-54 | Won | -0.7787 | -0.0000 |
| 25-Nov-05 | vs Morgan St (329) | 77-49 | Won | -2.0721 | -0.0000 |
| 28-Nov-05 | at Ohio State (11) | 56-69 | Lost | 1.8499 | 0.0000 |
| 04-Dec-05 | at Duke (1) | 75-77 | Lost | 2.3873 | 0.0000 |
| 07-Dec-05 | vs North Carolina A&T (320) | 94-66 | Won | -1.7481 | -0.0000 |
| 10-Dec-05 | vs St John's NY (119) | 73-64 | Won | -0.0615 | 0.6284 |
| 17-Dec-05 | at Stanford (72) | 59-52 | Won | 0.6656 | 1.0000 |
| 27-Dec-05 | vs William & Mary (242) | 74-64 | Won | -0.8335 | -0.0000 |
| 30-Dec-05 | at Old Dominion (56) | 55-58 | Lost | 1.1797 | -0.1305 |
| 02-Jan-06 | at James Madison (293) | 77-58 | Won | -0.5540 | 0.1359 |
| 07-Jan-06 | at Florida St (47) | 68-74 | Lost | 1.2864 | -0.0237 |
| 10-Jan-06 | vs North Carolina (16) | 61-64 | Lost | 1.0317 | -0.2784 |
| 15-Jan-06 | vs Virginia (75) | 49-54 | Lost | 0.3052 | -1.0000 |
| 21-Jan-06 | at Maryland (55) | 72-81 | Lost | 1.1820 | -0.1281 |
| 26-Jan-06 | vs Duke (1) | 67-80 | Lost | 1.6935 | 0.0000 |
| 28-Jan-06 | at Wake Forest (77) | 76-70 | Won | 0.9892 | 1.0000 |
| 31-Jan-06 | vs Georgia Tech (124) | 63-62 | Won | -0.0898 | 0.6001 |
| 04-Feb-06 | vs Boston College (19) | 73-74 | Lost | 1.0102 | -0.2999 |
| 08-Feb-06 | at Clemson (62) | 75-74 | Won | 1.1101 | 1.0000 |
| 11-Feb-06 | at Virginia (75) | 77-81 | Lost | 0.9989 | -0.3112 |
| 18-Feb-06 | vs North Carolina St (25) | 64-70 | Lost | 0.8537 | -0.4564 |
| 22-Feb-06 | at Miami FL (67) | 59-70 | Lost | 1.0621 | -0.2481 |
| 25-Feb-06 | vs Florida St (47) | 72-61 | Won | 0.5926 | 1.0000 |
| 01-Mar-06 | vs Clemson (62) | 81-86 | Lost | 0.4163 | -0.8938 |
| 04-Mar-06 | at Boston College (19) | 57-59 | Lost | 1.7040 | 0.0000 |
| 09-Mar-06 | at Virginia (75) | 56-60 | Lost | 0.6520 | -0.6581 |
A red opponent rating indicates modification according to home court advantage (0.3469).