| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Liberty (308) | 79-44 | Won | -1.5390 | -0.0000 |
| 22-Nov-05 | at Richmond (176) | 59-43 | Won | 0.2542 | 0.6022 |
| 27-Nov-05 | at Arizona (42) | 51-81 | Lost | 1.3374 | -0.3147 |
| 30-Nov-05 | vs Northwestern (86) | 72-57 | Won | 0.2218 | 0.5697 |
| 04-Dec-05 | at Georgia Tech (124) | 54-63 | Lost | 0.6040 | -1.0000 |
| 07-Dec-05 | vs Fordham (127) | 60-62 | Lost | -0.0971 | -1.0000 |
| 17-Dec-05 | at Gonzaga (12) | 69-80 | Lost | 1.8230 | 0.0000 |
| 23-Dec-05 | vs Loyola-Maryland (145) | 98-59 | Won | -0.2067 | 0.1412 |
| 28-Dec-05 | vs MD-Baltimore County (282) | 77-66 | Won | -0.7576 | -0.0000 |
| 31-Dec-05 | vs Hartford (280) | 71-62 | Won | -1.0964 | -0.0000 |
| 02-Jan-06 | at Western Kentucky (82) | 68-78 | Lost | 0.9672 | -0.6849 |
| 07-Jan-06 | vs Clemson (62) | 64-58 | Won | 0.4163 | 0.7643 |
| 11-Jan-06 | vs Florida St (47) | 82-87 | Lost | 0.5926 | -1.0000 |
| 15-Jan-06 | at Virginia Tech (117) | 54-49 | Won | 0.6570 | 1.0000 |
| 19-Jan-06 | vs North Carolina (16) | 72-68 | Won | 1.0317 | 1.0000 |
| 24-Jan-06 | vs Miami FL (67) | 71-51 | Won | 0.3683 | 0.7163 |
| 28-Jan-06 | at Duke (1) | 63-82 | Lost | 2.3873 | 0.0000 |
| 01-Feb-06 | at North Carolina St (25) | 64-66 | Lost | 1.5475 | -0.1046 |
| 04-Feb-06 | vs Wake Forest (77) | 75-73 | Won | 0.2954 | 0.6434 |
| 07-Feb-06 | at Maryland (55) | 65-76 | Lost | 1.1820 | -0.4700 |
| 11-Feb-06 | vs Virginia Tech (117) | 81-77 | Won | -0.0367 | 0.3112 |
| 15-Feb-06 | vs Longwood (303) | 91-56 | Won | -1.4046 | -0.0000 |
| 18-Feb-06 | at Florida St (47) | 62-76 | Lost | 1.2864 | -0.3656 |
| 21-Feb-06 | vs Boston College (19) | 72-58 | Won | 1.0102 | 1.0000 |
| 25-Feb-06 | at Clemson (62) | 64-90 | Lost | 1.1101 | -0.5420 |
| 01-Mar-06 | at North Carolina (16) | 54-99 | Lost | 1.7255 | 0.0000 |
| 05-Mar-06 | vs Maryland (55) | 70-71 | Lost | 0.4883 | -1.0000 |
| 09-Mar-06 | vs Virginia Tech (117) | 60-56 | Won | 0.3101 | 0.6581 |
| 10-Mar-06 | at North Carolina (16) | 67-79 | Lost | 1.3786 | -0.2734 |
| 14-Mar-06 | at Stanford (72) | 49-65 | Lost | 1.0125 | -0.6395 |
A red opponent rating indicates modification according to home court advantage (0.3469).