| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Nicholls St (282) | 99-65 | Won | -1.0998 | -0.0000 |
| 21-Nov-05 | vs Florida A&M (265) | 100-63 | Won | -1.0155 | -0.0000 |
| 26-Nov-05 | at Western Illinois (310) | 102-79 | Won | -0.8689 | -0.0000 |
| 30-Nov-05 | vs Duke (1) | 67-75 | Lost | 1.7812 | -0.4221 |
| 03-Dec-05 | vs Eastern Michigan (278) | 79-63 | Won | -1.0735 | -0.0000 |
| 06-Dec-05 | at Indiana St (136) | 67-72 | Lost | 0.5496 | -1.0000 |
| 10-Dec-05 | vs Kentucky (35) | 79-53 | Won | 1.0480 | 0.8446 |
| 19-Dec-05 | at Charlotte (92) | 71-54 | Won | 0.8907 | 0.6874 |
| 23-Dec-05 | at Butler (96) | 73-55 | Won | 0.5247 | 0.3214 |
| 31-Dec-05 | at Ball St (211) | 80-56 | Won | 0.0198 | -0.0000 |
| 03-Jan-06 | vs Michigan (30) | 70-63 | Won | 0.7391 | 0.5358 |
| 07-Jan-06 | vs Ohio State (6) | 81-79 | Won | 1.2974 | 1.0000 |
| 11-Jan-06 | at Michigan St (21) | 73-87 | Lost | 1.5617 | -0.6416 |
| 17-Jan-06 | vs Illinois (5) | 62-60 | Won | 1.2985 | 1.0000 |
| 21-Jan-06 | vs Purdue (143) | 62-49 | Won | -0.1687 | -0.0000 |
| 24-Jan-06 | at Iowa (10) | 60-73 | Lost | 1.8440 | -0.3594 |
| 29-Jan-06 | at Minnesota (68) | 42-61 | Lost | 1.0501 | -1.0000 |
| 01-Feb-06 | vs Northwestern (82) | 72-63 | Won | 0.2700 | 0.0667 |
| 04-Feb-06 | vs Connecticut (2) | 80-88 | Lost | 1.7054 | -0.4979 |
| 08-Feb-06 | at Wisconsin (28) | 54-72 | Lost | 1.4751 | -0.7282 |
| 11-Feb-06 | vs Iowa (10) | 67-70 | Lost | 1.1579 | -1.0000 |
| 15-Feb-06 | at Penn St (75) | 68-71 | Lost | 1.0168 | -1.0000 |
| 19-Feb-06 | at Illinois (5) | 58-70 | Lost | 1.9846 | -0.2187 |
| 22-Feb-06 | vs Penn St (75) | 69-65 | Won | 0.3308 | 0.1275 |
| 26-Feb-06 | vs Michigan St (21) | 78-71 | Won | 0.8756 | 0.6723 |
| 01-Mar-06 | at Purdue (143) | 70-59 | Won | 0.5174 | 0.3141 |
| 04-Mar-06 | at Michigan (30) | 69-67 | Won | 1.4252 | 1.0000 |
| 10-Mar-06 | at Wisconsin (28) | 61-56 | Won | 1.1321 | 0.9288 |
| 11-Mar-06 | vs Ohio State (6) | 51-52 | Lost | 1.6404 | -0.5629 |
A red opponent rating indicates modification according to home court advantage (0.3430).