| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Central Michigan (306) | 87-60 | Won | -1.4753 | -0.0000 |
| 22-Nov-05 | at Boston U. (241) | 51-46 | Won | -0.1504 | -0.0000 |
| 26-Nov-05 | vs Butler (96) | 78-74 | Won | 0.1817 | 0.0996 |
| 29-Nov-05 | vs Miami FL (76) | 74-53 | Won | 0.3257 | 0.2435 |
| 03-Dec-05 | at Notre Dame (64) | 71-67 | Won | 1.0583 | 0.9762 |
| 07-Dec-05 | vs Delaware St (167) | 69-49 | Won | -0.3690 | -0.0000 |
| 10-Dec-05 | at South Florida (229) | 68-47 | Won | -0.0737 | -0.0000 |
| 17-Dec-05 | vs UCLA (18) | 61-68 | Lost | 0.9985 | -1.0000 |
| 22-Dec-05 | vs Miami OH (87) | 87-80 | Won | 0.2262 | 0.1441 |
| 28-Dec-05 | vs Coppin St (279) | 81-53 | Won | -1.0762 | -0.0000 |
| 31-Dec-05 | vs Chicago St (226) | 86-69 | Won | -0.7481 | -0.0000 |
| 03-Jan-06 | at Indiana (24) | 63-70 | Lost | 1.5464 | -0.5358 |
| 07-Jan-06 | vs Purdue (143) | 68-65 | Won | -0.1687 | -0.0000 |
| 14-Jan-06 | at Illinois (5) | 74-79 | Lost | 1.9846 | -0.0975 |
| 18-Jan-06 | vs Northwestern (82) | 68-51 | Won | 0.2700 | 0.1879 |
| 21-Jan-06 | at Minnesota (68) | 71-55 | Won | 1.0501 | 0.9679 |
| 25-Jan-06 | vs Michigan St (21) | 72-67 | Won | 0.8756 | 0.7935 |
| 28-Jan-06 | vs Wisconsin (28) | 85-76 | Won | 0.7890 | 0.7069 |
| 01-Feb-06 | at Penn St (75) | 71-65 | Won | 1.0168 | 0.9347 |
| 04-Feb-06 | at Iowa (10) | 66-94 | Lost | 1.8440 | -0.2382 |
| 09-Feb-06 | vs Ohio State (6) | 85-94 | Lost | 1.2974 | -0.7847 |
| 11-Feb-06 | at Purdue (143) | 70-84 | Lost | 0.5174 | -1.0000 |
| 15-Feb-06 | vs Minnesota (68) | 72-50 | Won | 0.3640 | 0.2819 |
| 18-Feb-06 | at Michigan St (21) | 71-90 | Lost | 1.5617 | -0.5205 |
| 21-Feb-06 | vs Illinois (5) | 72-64 | Won | 1.2985 | 1.0000 |
| 25-Feb-06 | at Ohio State (6) | 54-64 | Lost | 1.9835 | -0.0987 |
| 04-Mar-06 | vs Indiana (24) | 67-69 | Lost | 0.8603 | -1.0000 |
| 09-Mar-06 | vs Minnesota (68) | 55-59 | Lost | 0.7070 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).