| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Wofford (271) | 82-75 | Won | -1.0585 | -0.0000 |
| 22-Nov-05 | vs South Alabama (62) | 85-67 | Won | 0.3906 | 1.0000 |
| 26-Nov-05 | vs Xavier OH (67) | 55-74 | Lost | 0.7071 | -0.4672 |
| 29-Nov-05 | at Florida St (36) | 57-97 | Lost | 1.3893 | 0.0000 |
| 03-Dec-05 | at Evansville (168) | 69-75 | Lost | 0.3163 | -0.8580 |
| 06-Dec-05 | vs Chicago St (226) | 69-56 | Won | -0.7481 | 0.0775 |
| 11-Dec-05 | at Loyola-Chicago (112) | 65-80 | Lost | 0.6873 | -0.4871 |
| 17-Dec-05 | vs New Orleans (219) | 68-56 | Won | -0.6909 | 0.1348 |
| 20-Dec-05 | vs IPFW (272) | 79-69 | Won | -1.0629 | -0.0000 |
| 28-Dec-05 | vs Tennessee-Martin (207) | 62-54 | Won | -0.6372 | 0.1884 |
| 30-Dec-05 | at Memphis (4) | 70-90 | Lost | 2.0433 | 0.0000 |
| 04-Jan-06 | at Northwestern (82) | 53-66 | Lost | 0.9561 | -0.2182 |
| 07-Jan-06 | at Michigan (30) | 65-68 | Lost | 1.4252 | 0.0000 |
| 11-Jan-06 | vs Ohio State (6) | 64-80 | Lost | 1.2974 | 0.0000 |
| 14-Jan-06 | vs Minnesota (68) | 72-55 | Won | 0.3640 | 1.0000 |
| 18-Jan-06 | at Penn St (75) | 54-74 | Lost | 1.0168 | -0.1575 |
| 21-Jan-06 | at Indiana (24) | 49-62 | Lost | 1.5464 | 0.0000 |
| 25-Jan-06 | vs Northwestern (82) | 76-78 | Lost | 0.2700 | -0.9043 |
| 28-Jan-06 | at Illinois (5) | 58-76 | Lost | 1.9846 | 0.0000 |
| 01-Feb-06 | vs Iowa (10) | 68-77 | Lost | 1.1579 | -0.0165 |
| 04-Feb-06 | vs Wisconsin (28) | 70-62 | Won | 0.7890 | 1.0000 |
| 08-Feb-06 | at Michigan St (21) | 52-77 | Lost | 1.5617 | 0.0000 |
| 11-Feb-06 | vs Michigan (30) | 84-70 | Won | 0.7391 | 1.0000 |
| 18-Feb-06 | vs Penn St (75) | 61-69 | Lost | 0.3308 | -0.8436 |
| 22-Feb-06 | at Minnesota (68) | 50-62 | Lost | 1.0501 | -0.1243 |
| 01-Mar-06 | vs Indiana (24) | 59-70 | Lost | 0.8603 | -0.3141 |
| 05-Mar-06 | at Ohio State (6) | 57-76 | Lost | 1.9835 | 0.0000 |
| 09-Mar-06 | at Michigan St (21) | 58-70 | Lost | 1.2186 | 0.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).