| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | at Hawai`i (101) | 62-84 | Lost | 0.7944 | -1.0000 |
| 22-Nov-05 | vs Gonzaga (11) | 106-109 | Lost | 1.4839 | -0.7347 |
| 23-Nov-05 | vs Arizona (50) | 74-71 | Won | 0.8790 | 0.6603 |
| 27-Nov-05 | vs IPFW (272) | 84-73 | Won | -1.0629 | -0.0000 |
| 30-Nov-05 | vs Georgia Tech (122) | 88-86 | Won | -0.0644 | -0.0000 |
| 03-Dec-05 | vs Arkansas-Little Rock (200) | 72-67 | Won | -0.2401 | -0.0000 |
| 06-Dec-05 | vs Boston College (16) | 77-70 | Won | 1.3883 | 1.0000 |
| 10-Dec-05 | vs Wichita St (34) | 83-64 | Won | 1.0544 | 0.8358 |
| 16-Dec-05 | vs Cleveland St (244) | 83-75 | Won | -0.8421 | -0.0000 |
| 18-Dec-05 | vs Florida Int'l (267) | 85-58 | Won | -1.0321 | -0.0000 |
| 21-Dec-05 | at UW-Green Bay (158) | 98-69 | Won | 0.3814 | 0.1627 |
| 28-Dec-05 | vs Tennessee Tech (148) | 80-63 | Won | -0.2227 | -0.0000 |
| 31-Dec-05 | vs Coppin St (279) | 78-54 | Won | -1.0762 | -0.0000 |
| 05-Jan-06 | at Illinois (5) | 50-60 | Lost | 1.9846 | -0.2340 |
| 08-Jan-06 | at Wisconsin (28) | 63-82 | Lost | 1.4751 | -0.7435 |
| 11-Jan-06 | vs Indiana (24) | 87-73 | Won | 0.8603 | 0.6416 |
| 15-Jan-06 | at Ohio State (6) | 62-59 | Won | 1.9835 | 1.0000 |
| 21-Jan-06 | vs Iowa (10) | 85-55 | Won | 1.1579 | 0.9393 |
| 25-Jan-06 | at Michigan (30) | 67-72 | Lost | 1.4252 | -0.7935 |
| 28-Jan-06 | vs Penn St (75) | 69-60 | Won | 0.3308 | 0.1121 |
| 04-Feb-06 | at Northwestern (82) | 77-66 | Won | 0.9561 | 0.7375 |
| 08-Feb-06 | vs Purdue (143) | 77-52 | Won | -0.1687 | -0.0000 |
| 11-Feb-06 | at Minnesota (68) | 55-69 | Lost | 1.0501 | -1.0000 |
| 14-Feb-06 | at Iowa (10) | 54-66 | Lost | 1.8440 | -0.3747 |
| 18-Feb-06 | vs Michigan (30) | 90-71 | Won | 0.7391 | 0.5205 |
| 22-Feb-06 | vs Ohio State (6) | 68-79 | Lost | 1.2974 | -0.9212 |
| 26-Feb-06 | at Indiana (24) | 71-78 | Lost | 1.5464 | -0.6723 |
| 02-Mar-06 | vs Wisconsin (28) | 74-65 | Won | 0.7890 | 0.5704 |
| 04-Mar-06 | vs Illinois (5) | 68-75 | Lost | 1.2985 | -0.9201 |
| 09-Mar-06 | vs Purdue (143) | 70-58 | Won | 0.1743 | -0.0000 |
| 10-Mar-06 | at Illinois (5) | 61-56 | Won | 1.6416 | 1.0000 |
| 11-Mar-06 | at Iowa (10) | 48-53 | Lost | 1.5009 | -0.7177 |
A red opponent rating indicates modification according to home court advantage (0.3430).