| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 14-Nov-05 | vs MD-Eastern Shore (318) | 86-41 | Won | -1.6511 | -0.0000 |
| 15-Nov-05 | vs Colgate (297) | 73-51 | Won | -1.2843 | -0.0000 |
| 21-Nov-05 | at Kentucky (35) | 67-63 | Won | 1.0480 | 0.5470 |
| 22-Nov-05 | at Texas (8) | 59-68 | Lost | 1.5457 | -0.9552 |
| 26-Nov-05 | vs Texas-San Antonio (250) | 79-46 | Won | -0.8945 | -0.0000 |
| 30-Nov-05 | vs North Carolina St (22) | 45-42 | Won | 0.8736 | 0.3727 |
| 02-Dec-05 | vs Fairfield (206) | 75-59 | Won | -0.6301 | -0.0000 |
| 03-Dec-05 | vs Valparaiso (193) | 72-59 | Won | -0.5397 | -0.0000 |
| 06-Dec-05 | at Northern Iowa (38) | 63-67 | Lost | 1.3739 | -1.0000 |
| 09-Dec-05 | at Iowa St (94) | 60-72 | Lost | 0.8789 | -1.0000 |
| 17-Dec-05 | vs Arizona St (164) | 62-43 | Won | -0.3384 | -0.0000 |
| 20-Dec-05 | vs Drake (161) | 65-60 | Won | -0.3337 | -0.0000 |
| 22-Dec-05 | vs Robert Morris PA (252) | 73-51 | Won | -0.9057 | -0.0000 |
| 30-Dec-05 | at St Louis (103) | 60-50 | Won | 0.7659 | 0.2650 |
| 05-Jan-06 | at Wisconsin (28) | 52-66 | Lost | 1.4751 | -1.0000 |
| 07-Jan-06 | vs Illinois (5) | 63-48 | Won | 1.2985 | 0.7976 |
| 14-Jan-06 | at Penn St (75) | 80-76 | Won | 1.0168 | 0.5159 |
| 18-Jan-06 | vs Minnesota (68) | 76-72 | Won | 0.3640 | -0.0000 |
| 21-Jan-06 | at Michigan St (21) | 55-85 | Lost | 1.5617 | -0.9393 |
| 24-Jan-06 | vs Indiana (24) | 73-60 | Won | 0.8603 | 0.3594 |
| 28-Jan-06 | vs Ohio State (6) | 67-62 | Won | 1.2974 | 0.7965 |
| 01-Feb-06 | at Purdue (143) | 77-68 | Won | 0.5174 | 0.0165 |
| 04-Feb-06 | vs Michigan (30) | 94-66 | Won | 0.7391 | 0.2382 |
| 08-Feb-06 | at Northwestern (82) | 48-51 | Lost | 0.9561 | -1.0000 |
| 11-Feb-06 | at Indiana (24) | 70-67 | Won | 1.5464 | 1.0000 |
| 14-Feb-06 | vs Michigan St (21) | 66-54 | Won | 0.8756 | 0.3747 |
| 18-Feb-06 | at Minnesota (68) | 61-74 | Lost | 1.0501 | -1.0000 |
| 25-Feb-06 | at Illinois (5) | 59-71 | Lost | 1.9846 | -0.5163 |
| 01-Mar-06 | vs Penn St (75) | 65-38 | Won | 0.3308 | -0.0000 |
| 04-Mar-06 | vs Wisconsin (28) | 59-44 | Won | 0.7890 | 0.2881 |
| 10-Mar-06 | vs Minnesota (68) | 67-57 | Won | 0.7070 | 0.2061 |
| 11-Mar-06 | vs Michigan St (21) | 53-48 | Won | 1.2186 | 0.7177 |
| 12-Mar-06 | at Ohio State (6) | 67-60 | Won | 1.6404 | 1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).