| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Dartmouth (307) | 80-61 | Won | -1.5227 | -0.0000 |
| 22-Nov-05 | vs Buffalo (118) | 92-63 | Won | -0.0358 | -0.0000 |
| 25-Nov-05 | vs Drake (161) | 87-84 | Won | 0.0094 | -0.0000 |
| 26-Nov-05 | at Oklahoma St (89) | 76-68 | Won | 0.5575 | 0.1692 |
| 03-Dec-05 | vs Sacred Heart (284) | 77-66 | Won | -1.1036 | -0.0000 |
| 06-Dec-05 | at Michigan St (21) | 70-77 | Lost | 1.2186 | -1.0000 |
| 11-Dec-05 | at Maryland (45) | 71-73 | Lost | 1.2623 | -1.0000 |
| 18-Dec-05 | vs Texas Southern (325) | 80-53 | Won | -1.8704 | -0.0000 |
| 22-Dec-05 | vs Harvard (251) | 89-55 | Won | -0.9017 | -0.0000 |
| 27-Dec-05 | at Duquesne (316) | 81-69 | Won | -0.9392 | -0.0000 |
| 31-Dec-05 | at Rhode Island (142) | 78-56 | Won | 0.5222 | 0.1339 |
| 03-Jan-06 | vs Massachusetts (125) | 91-62 | Won | -0.0822 | -0.0000 |
| 08-Jan-06 | at Georgia Tech (122) | 58-60 | Lost | 0.6217 | -1.0000 |
| 10-Jan-06 | vs North Carolina St (22) | 60-78 | Lost | 0.8736 | -1.0000 |
| 14-Jan-06 | vs Florida St (36) | 90-87 | Won | 0.7032 | 0.3148 |
| 17-Jan-06 | at Holy Cross (130) | 63-53 | Won | 0.5853 | 0.1969 |
| 21-Jan-06 | at Miami FL (76) | 65-61 | Won | 1.0117 | 0.6234 |
| 25-Jan-06 | at North Carolina (13) | 81-74 | Won | 1.8115 | 1.0000 |
| 29-Jan-06 | vs Georgia Tech (122) | 66-64 | Won | -0.0644 | -0.0000 |
| 01-Feb-06 | vs Duke (1) | 81-83 | Lost | 1.7812 | -0.6071 |
| 04-Feb-06 | at Virginia Tech (115) | 74-73 | Won | 0.6687 | 0.2804 |
| 08-Feb-06 | at Wake Forest (70) | 72-66 | Won | 1.0349 | 0.6466 |
| 11-Feb-06 | vs Clemson (59) | 67-61 | Won | 0.4415 | 0.0532 |
| 13-Feb-06 | vs Stony Brook (321) | 59-47 | Won | -1.7350 | -0.0000 |
| 16-Feb-06 | vs Miami FL (76) | 65-54 | Won | 0.3257 | -0.0000 |
| 21-Feb-06 | at Virginia (66) | 58-72 | Lost | 1.0534 | -1.0000 |
| 25-Feb-06 | at North Carolina St (22) | 74-72 | Won | 1.5597 | 1.0000 |
| 28-Feb-06 | vs Wake Forest (70) | 80-65 | Won | 0.3488 | -0.0000 |
| 04-Mar-06 | vs Virginia Tech (115) | 59-57 | Won | -0.0173 | -0.0000 |
| 10-Mar-06 | vs Maryland (45) | 80-66 | Won | 0.9192 | 0.5309 |
| 11-Mar-06 | at North Carolina (13) | 85-82 | Won | 1.4684 | 1.0000 |
| 12-Mar-06 | at Duke (1) | 76-78 | Lost | 2.1242 | -0.2641 |
A red opponent rating indicates modification according to home court advantage (0.3430).