| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 10-Nov-05 | vs Radford (204) | 80-50 | Won | -0.6185 | 0.0558 |
| 12-Nov-05 | vs Bowling Green (257) | 71-72 | Lost | -0.9245 | -1.0000 |
| 13-Nov-05 | vs Western Carolina (235) | 54-40 | Won | -0.7937 | -0.0000 |
| 18-Nov-05 | vs Mt St Mary's MD (253) | 74-62 | Won | -0.9114 | -0.0000 |
| 21-Nov-05 | vs Marshall (232) | 71-54 | Won | -0.7648 | -0.0000 |
| 25-Nov-05 | vs Morgan St (329) | 77-49 | Won | -2.0568 | -0.0000 |
| 28-Nov-05 | at Ohio State (6) | 56-69 | Lost | 1.9835 | 0.0000 |
| 04-Dec-05 | at Duke (1) | 75-77 | Lost | 2.4673 | 0.0000 |
| 07-Dec-05 | vs North Carolina A&T (322) | 94-66 | Won | -1.7355 | -0.0000 |
| 10-Dec-05 | vs St John's NY (123) | 73-64 | Won | -0.0736 | 0.6007 |
| 17-Dec-05 | at Stanford (84) | 59-52 | Won | 0.5753 | 1.0000 |
| 27-Dec-05 | vs William & Mary (246) | 74-64 | Won | -0.8610 | -0.0000 |
| 30-Dec-05 | at Old Dominion (73) | 55-58 | Lost | 1.0188 | -0.3069 |
| 02-Jan-06 | at James Madison (296) | 77-58 | Won | -0.5750 | 0.0992 |
| 07-Jan-06 | at Florida St (36) | 68-74 | Lost | 1.3893 | 0.0000 |
| 10-Jan-06 | vs North Carolina (13) | 61-64 | Lost | 1.1254 | -0.2003 |
| 15-Jan-06 | vs Virginia (66) | 49-54 | Lost | 0.3674 | -0.9584 |
| 21-Jan-06 | at Maryland (45) | 72-81 | Lost | 1.2623 | -0.0634 |
| 26-Jan-06 | vs Duke (1) | 67-80 | Lost | 1.7812 | 0.0000 |
| 28-Jan-06 | at Wake Forest (70) | 76-70 | Won | 1.0349 | 1.0000 |
| 31-Jan-06 | vs Georgia Tech (122) | 63-62 | Won | -0.0644 | 0.6099 |
| 04-Feb-06 | vs Boston College (16) | 73-74 | Lost | 1.0453 | -0.2804 |
| 08-Feb-06 | at Clemson (59) | 75-74 | Won | 1.1276 | 1.0000 |
| 11-Feb-06 | at Virginia (66) | 77-81 | Lost | 1.0534 | -0.2723 |
| 18-Feb-06 | vs North Carolina St (22) | 64-70 | Lost | 0.8736 | -0.4521 |
| 22-Feb-06 | at Miami FL (76) | 59-70 | Lost | 1.0117 | -0.3140 |
| 25-Feb-06 | vs Florida St (36) | 72-61 | Won | 0.7032 | 1.0000 |
| 01-Mar-06 | vs Clemson (59) | 81-86 | Lost | 0.4415 | -0.8842 |
| 04-Mar-06 | at Boston College (16) | 57-59 | Lost | 1.7314 | 0.0000 |
| 09-Mar-06 | at Virginia (66) | 56-60 | Lost | 0.7104 | -0.6153 |
A red opponent rating indicates modification according to home court advantage (0.3430).