| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Fairleigh Dickinson (170) | 111-85 | Won | -0.3942 | -0.0000 |
| 21-Nov-05 | vs Gonzaga (11) | 76-88 | Lost | 1.4839 | -0.4354 |
| 23-Nov-05 | vs Arkansas (29) | 75-62 | Won | 1.0911 | 1.0000 |
| 27-Nov-05 | vs Nicholls St (282) | 88-56 | Won | -1.0998 | -0.0000 |
| 30-Nov-05 | vs Minnesota (68) | 83-66 | Won | 0.3640 | 0.4447 |
| 05-Dec-05 | at George Washington (7) | 70-78 | Lost | 1.5961 | -0.3232 |
| 07-Dec-05 | vs Western Carolina (235) | 87-57 | Won | -0.7937 | -0.0000 |
| 11-Dec-05 | vs Boston College (16) | 73-71 | Won | 1.0453 | 1.0000 |
| 23-Dec-05 | vs American U. (239) | 81-55 | Won | -0.8254 | -0.0000 |
| 28-Dec-05 | vs Delaware St (167) | 68-54 | Won | -0.3690 | -0.0000 |
| 31-Dec-05 | vs VMI (315) | 99-68 | Won | -1.6121 | -0.0000 |
| 04-Jan-06 | vs TAMU-Corpus Christi (180) | 99-73 | Won | -0.4595 | -0.0000 |
| 07-Jan-06 | at Miami FL (76) | 70-84 | Lost | 1.0117 | -0.9075 |
| 11-Jan-06 | at Duke (1) | 52-76 | Lost | 2.4673 | 0.0000 |
| 15-Jan-06 | vs Wake Forest (70) | 90-86 | Won | 0.3488 | 0.4296 |
| 21-Jan-06 | vs Virginia Tech (115) | 81-72 | Won | -0.0173 | 0.0634 |
| 25-Jan-06 | at Georgia Tech (122) | 86-74 | Won | 0.6217 | 0.7024 |
| 28-Jan-06 | at Temple (74) | 85-91 | Lost | 1.0184 | -0.9008 |
| 02-Feb-06 | vs North Carolina (13) | 62-77 | Lost | 1.1254 | -0.7939 |
| 05-Feb-06 | at North Carolina St (22) | 58-62 | Lost | 1.5597 | -0.3596 |
| 07-Feb-06 | vs Virginia (66) | 76-65 | Won | 0.3674 | 0.4481 |
| 11-Feb-06 | vs Duke (1) | 88-96 | Lost | 1.7812 | -0.1381 |
| 14-Feb-06 | at Clemson (59) | 77-89 | Lost | 1.1276 | -0.7917 |
| 18-Feb-06 | vs Georgia Tech (122) | 87-84 | Won | -0.0644 | 0.0164 |
| 22-Feb-06 | at Florida St (36) | 60-71 | Lost | 1.3893 | -0.5300 |
| 26-Feb-06 | at North Carolina (13) | 57-81 | Lost | 1.8115 | -0.1078 |
| 01-Mar-06 | vs Miami FL (76) | 65-61 | Won | 0.3257 | 0.4064 |
| 05-Mar-06 | at Virginia (66) | 71-70 | Won | 1.0534 | 1.0000 |
| 09-Mar-06 | vs Georgia Tech (122) | 82-64 | Won | 0.2787 | 0.3594 |
| 10-Mar-06 | at Boston College (16) | 66-80 | Lost | 1.3883 | -0.5309 |
A red opponent rating indicates modification according to home court advantage (0.3430).