| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Liberty (309) | 79-44 | Won | -1.5285 | -0.0000 |
| 22-Nov-05 | at Richmond (176) | 59-43 | Won | 0.2549 | 0.5445 |
| 27-Nov-05 | at Arizona (50) | 51-81 | Lost | 1.2220 | -0.4884 |
| 30-Nov-05 | vs Northwestern (82) | 72-57 | Won | 0.2700 | 0.5596 |
| 04-Dec-05 | at Georgia Tech (122) | 54-63 | Lost | 0.6217 | -1.0000 |
| 07-Dec-05 | vs Fordham (132) | 60-62 | Lost | -0.1049 | -1.0000 |
| 17-Dec-05 | at Gonzaga (11) | 69-80 | Lost | 1.8269 | 0.0000 |
| 23-Dec-05 | vs Loyola-Maryland (147) | 98-59 | Won | -0.2198 | 0.0698 |
| 28-Dec-05 | vs MD-Baltimore County (283) | 77-66 | Won | -0.7606 | -0.0000 |
| 31-Dec-05 | vs Hartford (280) | 71-62 | Won | -1.0899 | -0.0000 |
| 02-Jan-06 | at Western Kentucky (79) | 68-78 | Lost | 0.9788 | -0.7316 |
| 07-Jan-06 | vs Clemson (59) | 64-58 | Won | 0.4415 | 0.7311 |
| 11-Jan-06 | vs Florida St (36) | 82-87 | Lost | 0.7032 | -1.0000 |
| 15-Jan-06 | at Virginia Tech (115) | 54-49 | Won | 0.6687 | 0.9584 |
| 19-Jan-06 | vs North Carolina (13) | 72-68 | Won | 1.1254 | 1.0000 |
| 24-Jan-06 | vs Miami FL (76) | 71-51 | Won | 0.3257 | 0.6153 |
| 28-Jan-06 | at Duke (1) | 63-82 | Lost | 2.4673 | 0.0000 |
| 01-Feb-06 | at North Carolina St (22) | 64-66 | Lost | 1.5597 | -0.1507 |
| 04-Feb-06 | vs Wake Forest (70) | 75-73 | Won | 0.3488 | 0.6384 |
| 07-Feb-06 | at Maryland (45) | 65-76 | Lost | 1.2623 | -0.4481 |
| 11-Feb-06 | vs Virginia Tech (115) | 81-77 | Won | -0.0173 | 0.2723 |
| 15-Feb-06 | vs Longwood (303) | 91-56 | Won | -1.3932 | -0.0000 |
| 18-Feb-06 | at Florida St (36) | 62-76 | Lost | 1.3893 | -0.3211 |
| 21-Feb-06 | vs Boston College (16) | 72-58 | Won | 1.0453 | 1.0000 |
| 25-Feb-06 | at Clemson (59) | 64-90 | Lost | 1.1276 | -0.5828 |
| 01-Mar-06 | at North Carolina (13) | 54-99 | Lost | 1.8115 | 0.0000 |
| 05-Mar-06 | vs Maryland (45) | 70-71 | Lost | 0.5762 | -1.0000 |
| 09-Mar-06 | vs Virginia Tech (115) | 60-56 | Won | 0.3257 | 0.6153 |
| 10-Mar-06 | at North Carolina (13) | 67-79 | Lost | 1.4684 | -0.2420 |
A red opponent rating indicates modification according to home court advantage (0.3430).