| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 13-Nov-05 | at Texas-Arlington (201) | 76-65 | Won | -0.2518 | 0.0795 |
| 14-Nov-05 | at Air Force (58) | 53-57 | Lost | 0.8220 | -0.8467 |
| 15-Nov-05 | at UW-Green Bay (158) | 80-54 | Won | 0.0383 | 0.3696 |
| 19-Nov-05 | vs Morgan St (329) | 83-51 | Won | -2.0568 | -0.0000 |
| 22-Nov-05 | vs North Carolina A&T (322) | 87-62 | Won | -1.7355 | -0.0000 |
| 27-Nov-05 | at Temple (74) | 56-73 | Lost | 1.0184 | -0.6503 |
| 29-Nov-05 | at Michigan (30) | 53-74 | Lost | 1.4252 | -0.2435 |
| 03-Dec-05 | vs Birmingham-Southern (154) | 82-55 | Won | -0.2851 | 0.0462 |
| 10-Dec-05 | vs Wofford (271) | 71-40 | Won | -1.0585 | -0.0000 |
| 18-Dec-05 | at North Carolina St (22) | 69-81 | Lost | 1.5597 | -0.1090 |
| 22-Dec-05 | vs Florida (9) | 67-77 | Lost | 1.1949 | -0.4738 |
| 27-Dec-05 | vs Stetson (298) | 65-56 | Won | -1.3051 | -0.0000 |
| 31-Dec-05 | vs Louisville (54) | 43-58 | Lost | 0.8559 | -0.8128 |
| 02-Jan-06 | vs Sacred Heart (284) | 63-57 | Won | -1.1036 | -0.0000 |
| 07-Jan-06 | vs Maryland (45) | 84-70 | Won | 0.5762 | 0.9075 |
| 14-Jan-06 | at North Carolina (13) | 81-70 | Won | 1.8115 | 1.0000 |
| 18-Jan-06 | vs Clemson (59) | 62-38 | Won | 0.4415 | 0.7728 |
| 21-Jan-06 | vs Boston College (16) | 61-65 | Lost | 1.0453 | -0.6234 |
| 24-Jan-06 | at Virginia (66) | 51-71 | Lost | 1.0534 | -0.6153 |
| 29-Jan-06 | at Florida St (36) | 84-78 | Won | 1.3893 | 1.0000 |
| 31-Jan-06 | vs Wake Forest (70) | 78-69 | Won | 0.3488 | 0.6801 |
| 04-Feb-06 | at Georgia Tech (122) | 70-53 | Won | 0.6217 | 0.9530 |
| 08-Feb-06 | vs North Carolina St (22) | 77-86 | Lost | 0.8736 | -0.7951 |
| 12-Feb-06 | vs North Carolina (13) | 70-80 | Lost | 1.1254 | -0.5433 |
| 16-Feb-06 | at Boston College (16) | 54-65 | Lost | 1.7314 | 0.0000 |
| 19-Feb-06 | at Duke (1) | 71-92 | Lost | 2.4673 | 0.0000 |
| 22-Feb-06 | vs Virginia Tech (115) | 70-59 | Won | -0.0173 | 0.3140 |
| 01-Mar-06 | at Maryland (45) | 61-65 | Lost | 1.2623 | -0.4064 |
| 05-Mar-06 | vs Florida St (36) | 64-67 | Lost | 0.7032 | -0.9655 |
| 09-Mar-06 | vs Clemson (59) | 66-63 | Won | 0.7845 | 1.0000 |
| 10-Mar-06 | at Duke (1) | 76-80 | Lost | 2.1242 | 0.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).