| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Marshall (232) | 91-81 | Won | -0.7648 | 0.2619 |
| 21-Nov-05 | at Loyola-Chicago (112) | 86-99 | Lost | 0.6873 | -0.2860 |
| 26-Nov-05 | at Marshall (232) | 67-70 | Lost | -0.0787 | -1.0000 |
| 03-Dec-05 | vs Purdue (143) | 75-69 | Won | -0.1687 | 0.8580 |
| 06-Dec-05 | at Western Kentucky (79) | 77-84 | Lost | 0.9788 | 0.0000 |
| 10-Dec-05 | vs Western Illinois (310) | 70-63 | Won | -1.5549 | -0.0000 |
| 17-Dec-05 | vs Campbell (311) | 83-71 | Won | -1.5565 | -0.0000 |
| 21-Dec-05 | at Austin Peay (175) | 71-74 | Lost | 0.2615 | -0.7118 |
| 28-Dec-05 | vs Drake (161) | 68-79 | Lost | -0.3337 | -1.0000 |
| 31-Dec-05 | at Northern Iowa (38) | 60-71 | Lost | 1.3739 | 0.0000 |
| 05-Jan-06 | vs Missouri St (42) | 65-80 | Lost | 0.6291 | -0.3442 |
| 07-Jan-06 | vs Indiana St (136) | 63-58 | Won | -0.1364 | 0.8903 |
| 11-Jan-06 | at Southern Illinois (32) | 38-66 | Lost | 1.4162 | 0.0000 |
| 14-Jan-06 | at Bradley (47) | 62-90 | Lost | 1.2474 | 0.0000 |
| 16-Jan-06 | at Illinois St (185) | 57-65 | Lost | 0.2127 | -0.7605 |
| 19-Jan-06 | vs Wichita St (34) | 62-69 | Lost | 0.7114 | -0.2619 |
| 22-Jan-06 | at Creighton (46) | 58-77 | Lost | 1.2595 | 0.0000 |
| 25-Jan-06 | vs Northern Iowa (38) | 61-74 | Lost | 0.6879 | -0.2854 |
| 28-Jan-06 | vs Bradley (47) | 76-79 | Lost | 0.5614 | -0.4119 |
| 01-Feb-06 | at Wichita St (34) | 66-74 | Lost | 1.3974 | 0.0000 |
| 04-Feb-06 | vs Illinois St (185) | 54-47 | Won | -0.4733 | 0.5534 |
| 07-Feb-06 | vs Creighton (46) | 56-60 | Lost | 0.5734 | -0.3998 |
| 11-Feb-06 | at Drake (161) | 69-68 | Won | 0.3524 | 1.0000 |
| 14-Feb-06 | at Missouri St (42) | 50-71 | Lost | 1.3152 | 0.0000 |
| 18-Feb-06 | vs Tennessee-Martin (207) | 62-69 | Lost | -0.6372 | -1.0000 |
| 21-Feb-06 | vs Southern Illinois (32) | 64-59 | Won | 0.7301 | 1.0000 |
| 25-Feb-06 | at Indiana St (136) | 77-75 | Won | 0.5496 | 1.0000 |
| 02-Mar-06 | vs Illinois St (185) | 52-45 | Won | -0.1303 | 0.8964 |
| 03-Mar-06 | at Southern Illinois (32) | 55-71 | Lost | 1.0731 | 0.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).