| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 20-Nov-05 | vs Austin Peay (175) | 66-46 | Won | -0.4246 | -0.0000 |
| 22-Nov-05 | vs Delaware St (167) | 49-42 | Won | -0.3690 | -0.0000 |
| 25-Nov-05 | at Kent St (53) | 55-52 | Won | 0.8568 | 1.0000 |
| 26-Nov-05 | at Illinois (5) | 57-77 | Lost | 1.6416 | -0.1909 |
| 30-Nov-05 | vs Temple (74) | 67-53 | Won | 0.3323 | 0.4999 |
| 03-Dec-05 | at St Mary's CA (110) | 75-69 | Won | 0.7205 | 0.8881 |
| 07-Dec-05 | vs MD-Eastern Shore (318) | 92-50 | Won | -1.6511 | -0.0000 |
| 10-Dec-05 | at Buffalo (118) | 53-62 | Lost | 0.6503 | -1.0000 |
| 15-Dec-05 | vs Maine (289) | 91-56 | Won | -1.1515 | -0.0000 |
| 17-Dec-05 | vs South Carolina St (233) | 63-45 | Won | -0.7696 | -0.0000 |
| 22-Dec-05 | vs Charlotte (92) | 82-85 | Lost | 0.2046 | -1.0000 |
| 31-Dec-05 | vs Princeton (220) | 54-44 | Won | -0.6996 | -0.0000 |
| 07-Jan-06 | vs Seton Hall (52) | 82-78 | Won | 0.5145 | 0.6821 |
| 11-Jan-06 | vs Villanova (3) | 78-84 | Lost | 1.5456 | -0.2868 |
| 15-Jan-06 | at DePaul (80) | 78-68 | Won | 0.9663 | 1.0000 |
| 18-Jan-06 | vs Pittsburgh (12) | 68-76 | Lost | 1.1341 | -0.6983 |
| 22-Jan-06 | at Cincinnati (41) | 66-71 | Lost | 1.3175 | -0.5150 |
| 25-Jan-06 | vs Providence RI (98) | 69-79 | Lost | 0.1506 | -1.0000 |
| 28-Jan-06 | vs Louisville (54) | 65-56 | Won | 0.5128 | 0.6804 |
| 01-Feb-06 | at Syracuse (20) | 84-86 | Lost | 1.6174 | -0.2150 |
| 05-Feb-06 | at Seton Hall (52) | 67-73 | Lost | 1.2006 | -0.6318 |
| 08-Feb-06 | at Notre Dame (64) | 63-90 | Lost | 1.0583 | -0.7741 |
| 12-Feb-06 | vs Marquette (31) | 91-84 | Won | 0.7360 | 0.9035 |
| 15-Feb-06 | vs St John's NY (123) | 51-54 | Lost | -0.0736 | -1.0000 |
| 18-Feb-06 | at South Florida (229) | 65-51 | Won | -0.0737 | 0.0939 |
| 22-Feb-06 | at Georgetown DC (19) | 50-66 | Lost | 1.6631 | -0.1693 |
| 26-Feb-06 | vs South Florida (229) | 62-44 | Won | -0.7598 | -0.0000 |
| 05-Mar-06 | at St John's NY (123) | 82-70 | Won | 0.6125 | 0.7801 |
| 08-Mar-06 | at Seton Hall (52) | 61-48 | Won | 0.8575 | 1.0000 |
| 09-Mar-06 | at Villanova (3) | 55-87 | Lost | 1.8886 | 0.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).