| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 21-Nov-05 | vs Vermont (237) | 87-77 | Won | -0.8106 | -0.0000 |
| 23-Nov-05 | vs New Hampshire (276) | 75-51 | Won | -1.0683 | -0.0000 |
| 28-Nov-05 | at Fairfield (206) | 81-78 | Won | 0.0560 | 0.5623 |
| 30-Nov-05 | at Wichita St (34) | 74-82 | Lost | 1.3974 | -0.0962 |
| 03-Dec-05 | at Rhode Island (142) | 69-77 | Lost | 0.5222 | -0.9715 |
| 06-Dec-05 | vs Florida (9) | 77-87 | Lost | 1.1949 | -0.2988 |
| 10-Dec-05 | vs Memphis (4) | 89-97 | Lost | 1.3572 | -0.1364 |
| 20-Dec-05 | vs Northeastern (104) | 92-70 | Won | 0.0711 | 0.5774 |
| 22-Dec-05 | vs Yale (234) | 76-63 | Won | -0.7762 | -0.0000 |
| 27-Dec-05 | vs San Diego St (63) | 80-65 | Won | 0.3814 | 0.8878 |
| 03-Jan-06 | vs Loyola-Maryland (147) | 94-81 | Won | -0.2198 | 0.2866 |
| 05-Jan-06 | at Georgetown DC (19) | 62-72 | Lost | 1.6631 | 0.0000 |
| 07-Jan-06 | vs Louisville (54) | 67-72 | Lost | 0.5128 | -0.9808 |
| 14-Jan-06 | at Notre Dame (64) | 77-92 | Lost | 1.0583 | -0.4353 |
| 17-Jan-06 | at West Virginia (26) | 48-64 | Lost | 1.5203 | 0.0000 |
| 21-Jan-06 | vs DePaul (80) | 76-75 | Won | 0.2802 | 0.7866 |
| 25-Jan-06 | at Rutgers (56) | 79-69 | Won | 1.1755 | 1.0000 |
| 28-Jan-06 | vs Connecticut (2) | 62-76 | Lost | 1.7054 | 0.0000 |
| 01-Feb-06 | vs Seton Hall (52) | 74-77 | Lost | 0.5145 | -0.9792 |
| 04-Feb-06 | vs St John's NY (123) | 81-73 | Won | -0.0736 | 0.4327 |
| 07-Feb-06 | at DePaul (80) | 61-60 | Won | 0.9663 | 1.0000 |
| 15-Feb-06 | vs Pittsburgh (12) | 77-85 | Lost | 1.1341 | -0.3595 |
| 17-Feb-06 | at Cincinnati (41) | 64-66 | Lost | 1.3175 | -0.1762 |
| 21-Feb-06 | vs South Florida (229) | 77-56 | Won | -0.7598 | -0.0000 |
| 25-Feb-06 | at Pittsburgh (12) | 68-81 | Lost | 1.8202 | 0.0000 |
| 01-Mar-06 | vs Notre Dame (64) | 75-82 | Lost | 0.3722 | -1.0000 |
| 04-Mar-06 | at Marquette (31) | 78-88 | Lost | 1.4220 | -0.0716 |
A red opponent rating indicates modification according to home court advantage (0.3430).