| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 19-Nov-05 | vs Bradley (47) | 60-75 | Lost | 0.5614 | -1.0000 |
| 26-Nov-05 | vs Northwestern (82) | 59-49 | Won | 0.2700 | 0.6467 |
| 28-Nov-05 | at Northern Illinois (114) | 68-77 | Lost | 0.6724 | -0.9509 |
| 30-Nov-05 | vs Creighton (46) | 72-57 | Won | 0.5734 | 0.9501 |
| 03-Dec-05 | vs Bucknell (25) | 52-57 | Lost | 0.8558 | -0.7675 |
| 06-Dec-05 | vs Alabama-Birmingham (44) | 70-66 | Won | 0.6056 | 0.9823 |
| 10-Dec-05 | at Dayton (159) | 61-54 | Won | 0.3639 | 0.7406 |
| 13-Dec-05 | at Wake Forest (70) | 84-81 | Won | 1.0349 | 1.0000 |
| 17-Dec-05 | at Old Dominion (73) | 43-87 | Lost | 1.0188 | -0.6045 |
| 21-Dec-05 | at California (43) | 68-65 | Won | 1.3128 | 1.0000 |
| 31-Dec-05 | vs Florida Int'l (267) | 72-60 | Won | -1.0321 | -0.0000 |
| 04-Jan-06 | at Cincinnati (41) | 60-82 | Lost | 1.3175 | -0.3058 |
| 07-Jan-06 | vs Notre Dame (64) | 73-67 | Won | 0.3722 | 0.7490 |
| 12-Jan-06 | at Pittsburgh (12) | 65-73 | Lost | 1.8202 | 0.0000 |
| 15-Jan-06 | vs Rutgers (56) | 68-78 | Lost | 0.4894 | -1.0000 |
| 17-Jan-06 | vs Marquette (31) | 79-82 | Lost | 0.7360 | -0.8873 |
| 21-Jan-06 | at Providence RI (98) | 75-76 | Lost | 0.8367 | -0.7866 |
| 25-Jan-06 | at Marquette (31) | 47-62 | Lost | 1.4220 | -0.2013 |
| 31-Jan-06 | vs Georgetown DC (19) | 44-64 | Lost | 0.9771 | -0.6462 |
| 03-Feb-06 | at South Florida (229) | 80-66 | Won | -0.0737 | 0.3030 |
| 07-Feb-06 | vs Providence RI (98) | 60-61 | Lost | 0.1506 | -1.0000 |
| 11-Feb-06 | vs Villanova (3) | 51-61 | Lost | 1.5456 | -0.0777 |
| 18-Feb-06 | at St John's NY (123) | 52-48 | Won | 0.6125 | 0.9892 |
| 22-Feb-06 | at Louisville (54) | 53-65 | Lost | 1.1989 | -0.4244 |
| 25-Feb-06 | vs Seton Hall (52) | 67-64 | Won | 0.5145 | 0.8912 |
| 02-Mar-06 | vs Syracuse (20) | 108-69 | Won | 0.9313 | 1.0000 |
| 04-Mar-06 | at Notre Dame (64) | 61-66 | Lost | 1.0583 | -0.5650 |
A red opponent rating indicates modification according to home court advantage (0.3430).