| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | at Navy (295) | 72-49 | Won | -0.5673 | -0.0000 |
| 21-Nov-05 | at James Madison (296) | 73-66 | Won | -0.5750 | -0.0000 |
| 26-Nov-05 | vs Vanderbilt (60) | 61-68 | Lost | 0.3972 | -1.0000 |
| 03-Dec-05 | at Oregon (119) | 71-57 | Won | 0.6489 | 0.3288 |
| 08-Dec-05 | at Illinois (5) | 48-58 | Lost | 1.9846 | -0.3355 |
| 11-Dec-05 | vs Fairfield (206) | 76-51 | Won | -0.6301 | -0.0000 |
| 17-Dec-05 | vs Stetson (298) | 70-50 | Won | -1.3051 | -0.0000 |
| 21-Dec-05 | vs Savannah St (334) | 78-49 | Won | -2.7451 | -0.0000 |
| 27-Dec-05 | at Colgate (297) | 61-45 | Won | -0.9413 | -0.0000 |
| 28-Dec-05 | at UTEP (97) | 76-64 | Won | 0.8460 | 0.5259 |
| 05-Jan-06 | vs Providence RI (98) | 72-62 | Won | 0.1506 | -0.0000 |
| 08-Jan-06 | at St John's NY (123) | 79-65 | Won | 0.6125 | 0.2924 |
| 11-Jan-06 | at West Virginia (26) | 61-68 | Lost | 1.5203 | -0.7999 |
| 14-Jan-06 | at Connecticut (2) | 67-74 | Lost | 2.3915 | 0.0000 |
| 17-Jan-06 | vs South Florida (229) | 50-47 | Won | -0.7598 | -0.0000 |
| 21-Jan-06 | vs Duke (1) | 87-84 | Won | 1.7812 | 1.0000 |
| 24-Jan-06 | at Notre Dame (64) | 85-82 | Won | 1.0583 | 0.7382 |
| 28-Jan-06 | vs Cincinnati (41) | 76-57 | Won | 0.6314 | 0.3113 |
| 31-Jan-06 | at DePaul (80) | 64-44 | Won | 0.9663 | 0.6462 |
| 05-Feb-06 | vs Pittsburgh (12) | 61-58 | Won | 1.1341 | 0.8140 |
| 09-Feb-06 | vs St John's NY (123) | 64-41 | Won | -0.0736 | -0.0000 |
| 12-Feb-06 | vs West Virginia (26) | 56-69 | Lost | 0.8342 | -1.0000 |
| 16-Feb-06 | at Marquette (31) | 51-57 | Lost | 1.4220 | -0.8981 |
| 19-Feb-06 | at Villanova (3) | 65-75 | Lost | 2.2317 | -0.0884 |
| 22-Feb-06 | vs Rutgers (56) | 66-50 | Won | 0.4894 | 0.1693 |
| 25-Feb-06 | vs Syracuse (20) | 68-53 | Won | 0.9313 | 0.6112 |
| 04-Mar-06 | at South Florida (229) | 56-63 | Lost | -0.0737 | -1.0000 |
| 09-Mar-06 | at Marquette (31) | 62-59 | Won | 1.0790 | 0.7589 |
| 10-Mar-06 | vs Syracuse (20) | 57-58 | Lost | 1.2743 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).