| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Stony Brook (321) | 78-35 | Won | -1.7350 | -0.0000 |
| 27-Nov-05 | vs Lehigh (172) | 84-47 | Won | -0.4023 | -0.0000 |
| 30-Nov-05 | vs Rider (224) | 86-57 | Won | -0.3880 | -0.0000 |
| 03-Dec-05 | vs Oklahoma (33) | 85-74 | Won | 0.7214 | -0.0000 |
| 06-Dec-05 | at Bucknell (25) | 79-60 | Won | 1.5419 | 0.6533 |
| 10-Dec-05 | vs Longwood (303) | 90-77 | Won | -1.0502 | -0.0000 |
| 13-Dec-05 | at Pennsylvania (121) | 62-55 | Won | 0.6239 | -0.0000 |
| 22-Dec-05 | vs La Salle (100) | 98-57 | Won | 0.1109 | -0.0000 |
| 31-Dec-05 | at Temple (74) | 75-53 | Won | 0.6754 | -0.0000 |
| 05-Jan-06 | at Louisville (54) | 76-67 | Won | 1.1989 | 0.3103 |
| 08-Jan-06 | vs West Virginia (26) | 87-91 | Lost | 0.8342 | -1.0000 |
| 11-Jan-06 | at Rutgers (56) | 84-78 | Won | 1.1755 | 0.2868 |
| 14-Jan-06 | at Texas (8) | 55-58 | Lost | 1.8887 | -0.9999 |
| 17-Jan-06 | vs Seton Hall (52) | 73-64 | Won | 0.5145 | -0.0000 |
| 21-Jan-06 | vs Syracuse (20) | 80-65 | Won | 0.9313 | 0.0427 |
| 24-Jan-06 | at South Florida (229) | 49-46 | Won | -0.0737 | -0.0000 |
| 28-Jan-06 | at Notre Dame (64) | 72-70 | Won | 1.0583 | 0.1697 |
| 30-Jan-06 | vs Louisville (54) | 79-73 | Won | 0.5128 | -0.0000 |
| 04-Feb-06 | vs Marquette (31) | 72-67 | Won | 0.7360 | -0.0000 |
| 07-Feb-06 | vs St Joseph's PA (55) | 71-58 | Won | 0.8486 | -0.0000 |
| 11-Feb-06 | at DePaul (80) | 61-51 | Won | 0.9663 | 0.0777 |
| 13-Feb-06 | vs Connecticut (2) | 69-64 | Won | 1.7054 | 0.8168 |
| 19-Feb-06 | vs Georgetown DC (19) | 75-65 | Won | 0.9771 | 0.0884 |
| 23-Feb-06 | at Cincinnati (41) | 74-72 | Won | 1.3175 | 0.4288 |
| 26-Feb-06 | at Connecticut (2) | 75-89 | Lost | 2.3915 | -0.4971 |
| 01-Mar-06 | vs St John's NY (123) | 65-52 | Won | -0.0736 | -0.0000 |
| 05-Mar-06 | at Syracuse (20) | 92-82 | Won | 1.6174 | 0.7288 |
| 09-Mar-06 | vs Rutgers (56) | 87-55 | Won | 0.8324 | -0.0000 |
| 10-Mar-06 | vs Pittsburgh (12) | 54-68 | Lost | 1.4772 | -1.0000 |
A red opponent rating indicates modification according to home court advantage (0.3430).