| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 18-Nov-05 | vs Lafayette (270) | 70-47 | Won | -1.0537 | -0.0000 |
| 21-Nov-05 | at Fairfield (206) | 72-41 | Won | 0.0560 | 0.2074 |
| 26-Nov-05 | at Davidson (117) | 94-100 | Lost | 0.6509 | -1.0000 |
| 29-Nov-05 | vs Drexel (140) | 69-59 | Won | 0.1882 | 0.3396 |
| 06-Dec-05 | at Kansas (17) | 70-67 | Won | 1.3874 | 1.0000 |
| 10-Dec-05 | vs Ohio State (6) | 74-81 | Lost | 1.2974 | -0.5512 |
| 21-Dec-05 | at Bucknell (25) | 51-63 | Lost | 1.5419 | -0.3067 |
| 28-Dec-05 | at St Mary's CA (110) | 70-66 | Won | 0.7205 | 0.8719 |
| 31-Dec-05 | at Gonzaga (11) | 94-102 | Lost | 1.8269 | -0.0217 |
| 04-Jan-06 | vs Xavier OH (67) | 58-62 | Lost | 0.3641 | -1.0000 |
| 08-Jan-06 | vs Temple (74) | 59-57 | Won | 0.3323 | 0.4838 |
| 11-Jan-06 | at Massachusetts (125) | 58-68 | Lost | 0.6038 | -1.0000 |
| 14-Jan-06 | at George Washington (7) | 70-82 | Lost | 1.9391 | 0.0000 |
| 17-Jan-06 | vs Charlotte (92) | 50-57 | Lost | 0.2046 | -1.0000 |
| 21-Jan-06 | vs La Salle (100) | 66-54 | Won | 0.4540 | 0.6054 |
| 25-Jan-06 | at St Louis (103) | 54-39 | Won | 0.7659 | 0.9173 |
| 28-Jan-06 | at Pennsylvania (121) | 47-44 | Won | 0.2809 | 0.4323 |
| 01-Feb-06 | at Dayton (159) | 69-77 | Lost | 0.3639 | -1.0000 |
| 04-Feb-06 | at St Bonaventure (242) | 82-51 | Won | -0.1523 | -0.0000 |
| 07-Feb-06 | at Villanova (3) | 58-71 | Lost | 1.8886 | 0.0000 |
| 11-Feb-06 | vs George Washington (7) | 62-64 | Lost | 1.2530 | -0.5955 |
| 14-Feb-06 | at Temple (74) | 44-57 | Lost | 1.0184 | -0.8302 |
| 18-Feb-06 | at Rhode Island (142) | 57-55 | Won | 0.5222 | 0.6736 |
| 22-Feb-06 | vs Fordham (132) | 64-58 | Won | -0.1049 | 0.0465 |
| 25-Feb-06 | vs Richmond (176) | 70-39 | Won | -0.4312 | -0.0000 |
| 28-Feb-06 | at Xavier OH (67) | 68-58 | Won | 1.0501 | 1.0000 |
| 04-Mar-06 | at Duquesne (316) | 79-63 | Won | -0.9392 | -0.0000 |
| 08-Mar-06 | vs Dayton (159) | 67-55 | Won | 0.0209 | 0.1723 |
| 09-Mar-06 | at St Louis (103) | 56-37 | Won | 0.4229 | 0.5743 |
| 10-Mar-06 | vs Temple (74) | 73-59 | Won | 0.6754 | 0.8268 |
| 11-Mar-06 | at Xavier OH (67) | 61-62 | Lost | 1.0501 | -0.7984 |
A red opponent rating indicates modification according to home court advantage (0.3430).