| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 12-Nov-05 | vs Louisiana-Monroe (256) | 88-69 | Won | -0.9211 | -0.0000 |
| 13-Nov-05 | vs Wofford (271) | 61-41 | Won | -1.0585 | -0.0000 |
| 21-Nov-05 | at Texas (8) | 75-76 | Lost | 1.5457 | -0.6315 |
| 22-Nov-05 | vs Kentucky (35) | 66-80 | Lost | 1.0480 | -1.0000 |
| 26-Nov-05 | vs LSU (14) | 68-71 | Lost | 1.0783 | -1.0000 |
| 30-Nov-05 | at St Bonaventure (242) | 66-61 | Won | -0.4953 | -0.0000 |
| 07-Dec-05 | vs MD-Baltimore County (283) | 82-53 | Won | -1.1036 | -0.0000 |
| 10-Dec-05 | vs Duquesne (316) | 86-66 | Won | -1.6253 | -0.0000 |
| 22-Dec-05 | at Oklahoma (33) | 92-68 | Won | 1.0645 | 0.8873 |
| 30-Dec-05 | vs Canisius (245) | 80-68 | Won | -0.8583 | -0.0000 |
| 05-Jan-06 | at South Florida (229) | 57-53 | Won | -0.0737 | -0.0000 |
| 08-Jan-06 | at Villanova (3) | 91-87 | Won | 2.2317 | 1.0000 |
| 11-Jan-06 | vs Georgetown DC (19) | 68-61 | Won | 0.9771 | 0.7999 |
| 14-Jan-06 | vs Marquette (31) | 104-85 | Won | 0.7360 | 0.5587 |
| 17-Jan-06 | vs Providence RI (98) | 64-48 | Won | 0.1506 | -0.0000 |
| 21-Jan-06 | at UCLA (18) | 60-56 | Won | 1.6846 | 1.0000 |
| 25-Jan-06 | vs Marshall (232) | 52-58 | Lost | -0.4218 | -1.0000 |
| 29-Jan-06 | at St John's NY (123) | 66-61 | Won | 0.6125 | 0.4353 |
| 01-Feb-06 | vs Notre Dame (64) | 71-70 | Won | 0.3722 | 0.1950 |
| 04-Feb-06 | vs Cincinnati (41) | 66-57 | Won | 0.6314 | 0.4542 |
| 09-Feb-06 | at Pittsburgh (12) | 53-57 | Lost | 1.8202 | -0.3570 |
| 12-Feb-06 | at Georgetown DC (19) | 69-56 | Won | 1.6631 | 1.0000 |
| 14-Feb-06 | at Seton Hall (52) | 64-71 | Lost | 1.2006 | -0.9766 |
| 18-Feb-06 | vs Connecticut (2) | 75-81 | Lost | 1.7054 | -0.4718 |
| 20-Feb-06 | at Syracuse (20) | 58-60 | Lost | 1.6174 | -0.5598 |
| 25-Feb-06 | vs Louisville (54) | 68-64 | Won | 0.5128 | 0.3356 |
| 27-Feb-06 | vs Pittsburgh (12) | 67-62 | Won | 1.1341 | 0.9569 |
| 04-Mar-06 | at Cincinnati (41) | 75-78 | Lost | 1.3175 | -0.8598 |
| 09-Mar-06 | vs Pittsburgh (12) | 57-68 | Lost | 1.4772 | -0.7000 |
A red opponent rating indicates modification according to home court advantage (0.3430).