| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | vs Miami OH (109) | 38-31 | Won | -1.83 | 0.00 |
| 16-Sep-06 | vs Ball St (87) | 38-28 | Won | -1.05 | 0.00 |
| 23-Sep-06 | vs Minnesota (38) | 27-21 | Won | 0.28 | 0.80 |
| 30-Sep-06 | at Notre Dame (10) | 21-35 | Lost | 2.15 | 0.00 |
| 07-Oct-06 | at Iowa (49) | 17-47 | Lost | 0.31 | -1.00 |
| 14-Oct-06 | at Northwestern (80) | 31-10 | Won | -0.31 | 0.21 |
| 21-Oct-06 | vs Wisconsin (6) | 3-24 | Lost | 1.99 | 0.00 |
| 28-Oct-06 | vs Penn State (14) | 0-12 | Lost | 1.28 | -0.20 |
| 04-Nov-06 | at Michigan St (72) | 17-15 | Won | -0.10 | 0.43 |
| 11-Nov-06 | at Illinois (100) | 42-31 | Won | -0.86 | 0.00 |
| 18-Nov-06 | vs Indiana (48) | 28-19 | Won | -0.12 | 0.41 |
| 25-Nov-06 | at Hawai`i (35) | 35-42 | Lost | 0.82 | -0.65 |
A red opponent rating indicates modification according to home field advantage (0.24).