| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Miami OH (109) | 21-3 | Won | -1.35 | 0.21 |
| 16-Sep-06 | vs Eastern Michigan (111) | 14-6 | Won | -1.98 | 0.00 |
| 22-Sep-06 | at Nevada (54) | 21-31 | Lost | 0.23 | -0.21 |
| 30-Sep-06 | at Penn State (14) | 7-33 | Lost | 1.76 | 0.00 |
| 07-Oct-06 | at Wisconsin (6) | 9-41 | Lost | 2.48 | 0.00 |
| 14-Oct-06 | vs Purdue (40) | 10-31 | Lost | 0.23 | -0.21 |
| 21-Oct-06 | vs Michigan St (72) | 38-41 | Lost | -0.59 | -1.00 |
| 28-Oct-06 | at Michigan (2) | 3-17 | Lost | 3.27 | 0.00 |
| 04-Nov-06 | at Iowa (49) | 21-7 | Won | 0.31 | 1.00 |
| 11-Nov-06 | vs Ohio State (1) | 10-54 | Lost | 3.48 | 0.00 |
| 18-Nov-06 | vs Illinois (100) | 27-16 | Won | -1.34 | 0.21 |
A red opponent rating indicates modification according to home field advantage (0.24).