| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Rutgers (22) | 0-33 | Lost | 1.35 | 0.00 |
| 16-Sep-06 | vs Syracuse (70) | 21-31 | Lost | -0.57 | -0.47 |
| 23-Sep-06 | vs Iowa (49) | 7-24 | Lost | -0.17 | -0.07 |
| 30-Sep-06 | at Michigan St (72) | 23-20 | Won | -0.10 | 1.00 |
| 07-Oct-06 | vs Indiana (48) | 32-34 | Lost | -0.12 | -0.02 |
| 14-Oct-06 | vs Ohio U. (60) | 17-20 | Lost | -0.36 | -0.25 |
| 21-Oct-06 | at Penn State (14) | 12-26 | Lost | 1.76 | 0.00 |
| 28-Oct-06 | at Wisconsin (6) | 24-30 | Lost | 2.48 | 0.00 |
| 04-Nov-06 | vs Ohio State (1) | 10-17 | Lost | 3.48 | 0.00 |
| 11-Nov-06 | vs Purdue (40) | 31-42 | Lost | 0.23 | 0.00 |
| 18-Nov-06 | at Northwestern (80) | 16-27 | Lost | -0.31 | -0.21 |
A red opponent rating indicates modification according to home field advantage (0.24).