| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Western Michigan (64) | 39-20 | Won | -0.44 | 0.44 |
| 09-Sep-06 | at Ball St (87) | 24-23 | Won | -0.57 | 0.31 |
| 23-Sep-06 | vs Connecticut (68) | 7-14 | Lost | -0.52 | -1.00 |
| 30-Sep-06 | vs Wisconsin (6) | 17-52 | Lost | 1.99 | 0.00 |
| 07-Oct-06 | at Illinois (100) | 34-32 | Won | -0.86 | 0.02 |
| 14-Oct-06 | vs Iowa (49) | 31-28 | Won | -0.17 | 0.71 |
| 21-Oct-06 | at Ohio State (1) | 3-44 | Lost | 3.96 | 0.00 |
| 28-Oct-06 | vs Michigan St (72) | 46-21 | Won | -0.59 | 0.29 |
| 04-Nov-06 | at Minnesota (38) | 26-63 | Lost | 0.76 | -0.36 |
| 11-Nov-06 | vs Michigan (2) | 3-34 | Lost | 2.78 | 0.00 |
| 18-Nov-06 | at Purdue (40) | 19-28 | Lost | 0.71 | -0.41 |
A red opponent rating indicates modification according to home field advantage (0.24).