| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Kent St (98) | 44-0 | Won | -0.81 | 0.00 |
| 09-Sep-06 | at California (11) | 17-42 | Lost | 2.04 | 0.00 |
| 16-Sep-06 | vs Temple (116) | 62-0 | Won | -2.25 | 0.00 |
| 23-Sep-06 | at Purdue (40) | 21-27 | Lost | 0.71 | -0.80 |
| 30-Sep-06 | vs Michigan (2) | 14-28 | Lost | 2.78 | 0.00 |
| 07-Oct-06 | vs Penn State (14) | 27-28 | Lost | 1.28 | -0.24 |
| 14-Oct-06 | at Wisconsin (6) | 12-48 | Lost | 2.48 | 0.00 |
| 28-Oct-06 | at Ohio State (1) | 0-44 | Lost | 3.96 | 0.00 |
| 04-Nov-06 | vs Indiana (48) | 63-26 | Won | -0.12 | 0.36 |
| 11-Nov-06 | at Michigan St (72) | 31-18 | Won | -0.10 | 0.38 |
| 18-Nov-06 | vs Iowa (49) | 34-24 | Won | -0.17 | 0.31 |
A red opponent rating indicates modification according to home field advantage (0.24).