| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Vanderbilt (56) | 27-7 | Won | -0.30 | 0.00 |
| 09-Sep-06 | vs Central Michigan (55) | 41-17 | Won | -0.27 | 0.00 |
| 16-Sep-06 | at Notre Dame (10) | 47-21 | Won | 2.15 | 0.12 |
| 23-Sep-06 | vs Wisconsin (6) | 27-13 | Won | 1.99 | 0.00 |
| 30-Sep-06 | at Minnesota (38) | 28-14 | Won | 0.76 | 0.00 |
| 07-Oct-06 | vs Michigan St (72) | 31-13 | Won | -0.59 | 0.00 |
| 14-Oct-06 | at Penn State (14) | 17-10 | Won | 1.76 | 0.00 |
| 21-Oct-06 | vs Iowa (49) | 20-6 | Won | -0.17 | 0.00 |
| 28-Oct-06 | vs Northwestern (80) | 17-3 | Won | -0.80 | 0.00 |
| 04-Nov-06 | vs Ball St (87) | 34-26 | Won | -1.05 | 0.00 |
| 11-Nov-06 | at Indiana (48) | 34-3 | Won | 0.36 | 0.00 |
| 18-Nov-06 | at Ohio State (1) | 39-42 | Lost | 3.96 | -0.07 |
A red opponent rating indicates modification according to home field advantage (0.24).