| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Boston College (29) | 24-31 | Lost | 0.71 | -0.26 |
| 09-Sep-06 | at Michigan (2) | 17-41 | Lost | 3.27 | 0.00 |
| 16-Sep-06 | vs Akron (102) | 24-21 | Won | -1.43 | 0.00 |
| 23-Sep-06 | at Eastern Michigan (111) | 24-17 | Won | -1.50 | 0.00 |
| 30-Sep-06 | at Kentucky (32) | 36-45 | Lost | 0.94 | -0.03 |
| 07-Oct-06 | at Toledo (104) | 42-20 | Won | -0.99 | 0.03 |
| 14-Oct-06 | vs Ball St (87) | 18-7 | Won | -1.05 | 0.00 |
| 19-Oct-06 | vs Bowling Green (113) | 31-14 | Won | -2.08 | 0.00 |
| 04-Nov-06 | at Temple (116) | 42-26 | Won | -1.77 | 0.00 |
| 10-Nov-06 | vs Western Michigan (64) | 31-7 | Won | -0.44 | 0.59 |
| 17-Nov-06 | at Northern Illinois (81) | 10-31 | Lost | -0.33 | -1.00 |
| 24-Nov-06 | at Buffalo (115) | 55-28 | Won | -1.69 | 0.00 |
| 30-Nov-06 | vs Ohio U. (60) | 31-10 | Won | -0.36 | 0.67 |
A red opponent rating indicates modification according to home field advantage (0.24).