| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (1) | 12-35 | Lost | 3.96 | 0.00 |
| 09-Sep-06 | vs Ohio U. (60) | 23-35 | Lost | -0.36 | -0.79 |
| 16-Sep-06 | vs Buffalo (115) | 31-13 | Won | -2.17 | 0.00 |
| 30-Sep-06 | at Ball St (87) | 40-28 | Won | -0.57 | 1.00 |
| 08-Oct-06 | at Miami OH (109) | 28-25 | Won | -1.35 | 0.22 |
| 14-Oct-06 | at Western Michigan (64) | 14-16 | Lost | 0.05 | -0.39 |
| 21-Oct-06 | vs Temple (116) | 43-21 | Won | -2.25 | 0.00 |
| 28-Oct-06 | at Iowa (49) | 14-24 | Lost | 0.31 | -0.12 |
| 07-Nov-06 | vs Toledo (104) | 13-17 | Lost | -1.48 | -1.00 |
| 17-Nov-06 | vs Central Michigan (55) | 31-10 | Won | -0.27 | 1.00 |
| 24-Nov-06 | at Eastern Michigan (111) | 27-0 | Won | -1.50 | 0.07 |
A red opponent rating indicates modification according to home field advantage (0.24).