| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Northwestern (80) | 3-21 | Lost | -0.80 | -0.21 |
| 09-Sep-06 | at Purdue (40) | 31-38 | Lost | 0.71 | 0.00 |
| 16-Sep-06 | vs Kent St (98) | 14-16 | Lost | -1.29 | -0.70 |
| 23-Sep-06 | at Syracuse (70) | 14-34 | Lost | -0.09 | 0.00 |
| 30-Sep-06 | at Cincinnati (34) | 10-24 | Lost | 0.82 | 0.00 |
| 08-Oct-06 | vs Northern Illinois (81) | 25-28 | Lost | -0.81 | -0.22 |
| 15-Oct-06 | at Buffalo (115) | 38-31 | Won | -1.69 | 0.91 |
| 21-Oct-06 | at Akron (102) | 13-24 | Lost | -0.94 | -0.35 |
| 28-Oct-06 | vs Ball St (87) | 17-20 | Lost | -1.05 | -0.46 |
| 04-Nov-06 | at Western Michigan (64) | 24-27 | Lost | 0.05 | 0.00 |
| 15-Nov-06 | at Bowling Green (113) | 9-7 | Won | -1.60 | 0.99 |
| 24-Nov-06 | vs Ohio U. (60) | 24-34 | Lost | -0.36 | 0.00 |
A red opponent rating indicates modification according to home field advantage (0.24).