| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 08-Sep-06 | vs Pittsburgh (59) | 15-33 | Lost | -0.31 | -1.00 |
| 16-Sep-06 | at Ohio State (1) | 7-37 | Lost | 3.96 | 0.00 |
| 23-Sep-06 | at Virginia Tech (28) | 13-29 | Lost | 1.20 | -0.38 |
| 30-Sep-06 | vs Miami OH (109) | 24-10 | Won | -1.83 | 0.00 |
| 07-Oct-06 | vs Akron (102) | 20-14 | Won | -1.43 | 0.00 |
| 14-Oct-06 | at Louisville (18) | 17-23 | Lost | 1.47 | -0.12 |
| 22-Oct-06 | vs South Florida (45) | 23-6 | Won | 0.03 | 0.45 |
| 28-Oct-06 | vs Syracuse (70) | 17-3 | Won | -0.57 | 0.00 |
| 11-Nov-06 | at West Virginia (25) | 24-42 | Lost | 1.26 | -0.33 |
| 18-Nov-06 | vs Rutgers (22) | 30-11 | Won | 0.87 | 1.00 |
| 25-Nov-06 | at Connecticut (68) | 26-23 | Won | -0.04 | 0.38 |
A red opponent rating indicates modification according to home field advantage (0.24).