| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (70) | 20-13 | Won | -0.09 | 0.84 |
| 16-Sep-06 | vs Iowa St (97) | 27-17 | Won | -1.28 | 0.00 |
| 23-Sep-06 | at Illinois (100) | 24-7 | Won | -0.86 | 0.07 |
| 30-Sep-06 | vs Ohio State (1) | 17-38 | Lost | 3.48 | 0.00 |
| 07-Oct-06 | vs Purdue (40) | 47-17 | Won | 0.23 | 1.00 |
| 14-Oct-06 | at Indiana (48) | 28-31 | Lost | 0.36 | -0.71 |
| 21-Oct-06 | at Michigan (2) | 6-20 | Lost | 3.27 | 0.00 |
| 28-Oct-06 | vs Northern Illinois (81) | 24-14 | Won | -0.81 | 0.12 |
| 04-Nov-06 | vs Northwestern (80) | 7-21 | Lost | -0.80 | -1.00 |
| 11-Nov-06 | vs Wisconsin (6) | 21-24 | Lost | 1.99 | 0.00 |
| 18-Nov-06 | at Minnesota (38) | 24-34 | Lost | 0.76 | -0.31 |
A red opponent rating indicates modification according to home field advantage (0.24).