| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Akron (102) | 34-16 | Won | -1.43 | 0.00 |
| 09-Sep-06 | at Notre Dame (10) | 17-41 | Lost | 2.15 | -0.37 |
| 23-Sep-06 | at Ohio State (1) | 6-28 | Lost | 3.96 | 0.00 |
| 30-Sep-06 | vs Northwestern (80) | 33-7 | Won | -0.80 | 0.00 |
| 07-Oct-06 | at Minnesota (38) | 28-27 | Won | 0.76 | 0.24 |
| 14-Oct-06 | vs Michigan (2) | 10-17 | Lost | 2.78 | 0.00 |
| 21-Oct-06 | vs Illinois (100) | 26-12 | Won | -1.34 | 0.00 |
| 28-Oct-06 | at Purdue (40) | 12-0 | Won | 0.71 | 0.20 |
| 04-Nov-06 | at Wisconsin (6) | 3-13 | Lost | 2.48 | -0.04 |
| 11-Nov-06 | vs Temple (116) | 47-0 | Won | -2.25 | 0.00 |
| 18-Nov-06 | vs Michigan St (72) | 17-13 | Won | -0.59 | 0.00 |
A red opponent rating indicates modification according to home field advantage (0.24).