| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Ohio U. (93) | 38-14 | Won | -0.9384 | -0.0000 |
| 10-Sep-05 | vs Northern Illinois (56) | 38-37 | Won | -0.0298 | -0.0000 |
| 17-Sep-05 | at Arizona St (26) | 21-52 | Lost | 0.9953 | -1.0000 |
| 24-Sep-05 | vs Penn State (3) | 29-34 | Lost | 2.0191 | -0.2847 |
| 08-Oct-05 | vs Wisconsin (10) | 51-48 | Won | 1.2683 | 0.9644 |
| 15-Oct-05 | at Purdue (34) | 34-29 | Won | 0.7863 | 0.4824 |
| 22-Oct-05 | at Michigan St (37) | 49-14 | Won | 0.7215 | 0.4176 |
| 29-Oct-05 | vs Michigan (12) | 17-33 | Lost | 1.2396 | -1.0000 |
| 05-Nov-05 | vs Iowa (21) | 28-27 | Won | 0.9682 | 0.6644 |
| 12-Nov-05 | at Ohio State (4) | 7-48 | Lost | 2.1236 | -0.1802 |
| 19-Nov-05 | at Illinois (66) | 38-21 | Won | 0.0018 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1322).