| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Kent St (119) | 49-14 | Won | -3.1276 | -0.0000 |
| 10-Sep-05 | vs Hawai`i (89) | 42-14 | Won | -0.7406 | -0.0000 |
| 17-Sep-05 | at Notre Dame (6) | 44-41 | Won | 1.8496 | 1.0000 |
| 24-Sep-05 | at Illinois (66) | 61-14 | Won | 0.0018 | 0.4125 |
| 01-Oct-05 | vs Michigan (12) | 31-34 | Lost | 1.2396 | -0.3497 |
| 15-Oct-05 | at Ohio State (4) | 24-35 | Lost | 2.1236 | 0.0000 |
| 22-Oct-05 | vs Northwestern (15) | 14-49 | Lost | 1.1717 | -0.4176 |
| 29-Oct-05 | vs Indiana (47) | 46-15 | Won | 0.0997 | 0.5104 |
| 05-Nov-05 | at Purdue (34) | 21-28 | Lost | 0.7863 | -0.8030 |
| 12-Nov-05 | at Minnesota (18) | 18-41 | Lost | 1.2671 | -0.3222 |
| 19-Nov-05 | vs Penn State (3) | 22-31 | Lost | 2.0191 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1322).