| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Miami OH (71) | 34-14 | Won | -0.3788 | -0.0000 |
| 10-Sep-05 | vs Texas (1) | 22-25 | Lost | 2.8351 | -0.1563 |
| 17-Sep-05 | vs San Diego St (84) | 27-6 | Won | -0.6461 | -0.0000 |
| 24-Sep-05 | vs Iowa (21) | 31-6 | Won | 0.9682 | -0.0000 |
| 08-Oct-05 | at Penn State (3) | 10-17 | Lost | 2.2836 | -0.7079 |
| 15-Oct-05 | vs Michigan St (37) | 35-24 | Won | 0.4571 | -0.0000 |
| 22-Oct-05 | at Indiana (47) | 41-10 | Won | 0.3641 | -0.0000 |
| 29-Oct-05 | at Minnesota (18) | 45-31 | Won | 1.2671 | 0.2756 |
| 05-Nov-05 | vs Illinois (66) | 40-2 | Won | -0.2626 | -0.0000 |
| 12-Nov-05 | vs Northwestern (15) | 48-7 | Won | 1.1717 | 0.1802 |
| 19-Nov-05 | at Michigan (12) | 25-21 | Won | 1.5040 | 0.5126 |
A red opponent rating indicates modification according to home field advantage (0.1322).